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Particle timing and spacing control in microchannel flow by applying periodic force over space and time
Microfluidics and Nanofluidics ( IF 2.8 ) Pub Date : 2021-01-23 , DOI: 10.1007/s10404-020-02416-5
Kazuya Tatsumi , Atsushi Noma , Renato Honma , Reiko Kuriyama , Kazuyoshi Nakabe

This study develops a technique to control the timing, spacing (interval), and velocity of particles in a microchannel flow by periodically exerting forces on the particles over space and time. The periodic force was produced by dielectrophoretic force using boxcar-shaped electrodes on the channel wall. We could define the timing, interval, and velocity of the particles by configuring the on–off cycles of the applied voltage. Controlling the particle spacing and timing when it crosses a position in the channel and the focusing effect in the cross-sectional position could improve the performance and throughput of microfluidics, particularly for sensing, active sorting, and encapsulation of particles and cells. The proposed technique was first evaluated by a one-dimensional analysis based on a perturbation theory. We conducted a numerical simulation to solve the dielectrophoretic force distribution and the equation of motion of the particles to understand the relationship between the force and the particle motion in the boxcar-electrode region. We measured the velocity and position of the micro-particles flowing over the boxcar-electrode region in the microchannel and demonstrated the performance and accuracy of the proposed technique for alignment and timing control. The probability density functions (PDFs) of the period between the particles, particle velocity, and timing, concentrated at the target value with minimal variation. Furthermore, the measurement of particles with diameters of 8, 10, and 12 μm resulted in the same PDFs, which showed the applicability to a reasonable variation of particle diameters.



中文翻译:

通过在空间和时间上施加周期性的力来控制微通道流动中的颗粒定时和间隔

这项研究开发了一种通过在空间和时间上周期性地向粒子施加力来控制微通道流动中粒子的时间,间隔(间隔)和速度的技术。使用通道壁上的箱形电极通过介电泳力产生周期性力。我们可以通过配置施加电压的开-关循环来定义粒子的时间,间隔和速度。控制微粒的间距和时间,使其在通道中穿过某个位置时以及在横截位置中的聚焦效果时,可以提高微流体的性能和通量,特别是对于传感,主动分选以及微粒和细胞的封装而言。首先通过基于扰动理论的一维分析对提出的技术进行了评估。我们进行了数值模拟,以解决介电泳力分布和粒子的运动方程,以了解力和粒子在盒车电极区域中的运动之间的关系。我们测量了微通道中盒车电极区域上流过的微粒的速度和位置,并证明了所提出的对准和时序控制技术的性能和准确性。粒子之间的时间间隔,粒子速度和时间的概率密度函数(PDF)以最小的变化集中在目标值上。此外,对直径分别为8、10和12μm的颗粒进行测量得到了相同的PDF,这表明适用于合理地改变粒径。

更新日期:2021-01-24
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