The advantages of mesoporous hydroxyapatite and the thermo-responsive property of poly-N-isopropylacrylamide make them attractive in drug delivery system, respectively. In this work, mesoporous poly-N-isopropylacrylamide-hydroxyapatite composite microspheres (PNIPAM-m-HAP) were synthesized, characterized and applied as a drug carrier. Doxorubicin was selected as a typical anticancer drug to study the in-vitro release characteristics of drug from PNIPAM-m-HAP in PBS. The release mechanism and release kinetics was also studied. Furthermore, the biocompatibility of the PNIPAM-m-HAP material was evaluated by MTT method. The experimental results depicted that the synthesized PNIPAM-m-HAP material was biocompatible, pH and thermo-responsive, which showed controlled release of doxorubicin.

介孔羟基磷灰石的优点和聚N-异丙基丙烯酰胺的热响应特性使其分别在药物递送系统中具有吸引力。在这项工作中，合成了介孔的聚-N-异丙基丙烯酰胺-羟基磷灰石复合微球（PNIPAM-m-HAP），表征并用作药物载体。选择阿霉素作为典型的抗癌药物，以研究该药物在PBS中从PNIPAM-m-HAP的体外释放特性。还研究了释放机理和释放动力学。此外，通过MTT法评价了PNIPAM-m-HAP材料的生物相容性。实验结果表明，所合成的PNIPAM-m-HAP材料具有生物相容性，pH值和热响应性，表明阿霉素的控制释放。