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CS/Au/MWCNT nanohybrid as an efficient carrier for the sustained release of 5-FU and a study of its cytotoxicity on MCF-7
RSC Advances ( IF 3.9 ) Pub Date : 2021-1-22 , DOI: 10.1039/d0ra08537e
E A K Nivethaa 1, 2 , S Dhanavel 2, 3 , V Narayanan 4 , S Narayana Kalkura 5 , J Sivasankari 1 , N Sivanandham 1 , A Stephen 2
Affiliation  

The chemical reduction method has been used to adeptly synthesize a CS/Au/MWCNT nanocomposite, to be used as a carrier for the effectual delivery of the anticancer drug 5-Fluorouracil. The work aims at utilizing the less investigated ternary nanocomposite system containing chitosan (CS), gold (Au) and MWCNT's to attain higher encapsulation efficiency and to enable a more sustained and prolonged release of 5-FU. This system has improved cytotoxicity when compared to the CS/Au binary system. The prepared sample has been characterized using various techniques that confirm the formation of the nanocomposite, encapsulation of 5-FU into the nanocomposite, the structure of 5-FU and Au in the nanocomposite and the formation of the polymer matrix nanocomposite. An increase in the encapsulation efficiency to 98% and loading efficiency to 43% is observed when compared to the binary composite, elucidating the importance of incorporation of carbon nanotubes into the nanocomposite. A reduction in the release percentage of 5-FU by 40% indicates a more prolonged release, which will enable a reduction of the number of dosages that need to be administered. This in turn leads to a reduction in the side effects posed by the drug 5-FU. Moreover, the effectiveness of the drug loaded nanocomposite system towards the inhibition of breast cancer cells, apparent from the attainment of 50% cell viability while taking sample concentrations as low as 25 μg ml−1, makes this ternary nanocomposite superior and significant.

中文翻译:

CS/Au/MWCNT纳米杂化物作为5-FU缓释的有效载体及其对MCF-7的细胞毒性研究

化学还原法已被用来熟练地合成 CS/Au/MWCNT 纳米复合材料,用作有效递送抗癌药物 5-氟尿嘧啶的载体。该工作旨在利用研究较少的含有壳聚糖 (CS)、金 (Au) 和多壁碳纳米管的三元纳米复合系统来获得更高的封装效率,并使 5-FU 的释放更持久和更持久。与 CS/Au 二元系统相比,该系统具有改善的细胞毒性。使用各种技术对制备的样品进行了表征,这些技术证实了纳米复合材料的形成、5-FU 封装到纳米复合材料中、纳米复合材料中 5-FU 和 Au 的结构以及聚合物基质纳米复合材料的形成。与二元复合材料相比,封装效率提高到 98%,负载效率提高到 43%,阐明了将碳纳米管结合到纳米复合材料中的重要性。5-FU 的释放百分比降低 40% 表明释放时间更长,这将能够减少需要给药的剂量数量。这反过来导致药物 5-FU 引起的副作用减少。此外,载药纳米复合系统对抑制乳腺癌细胞的有效性,从达到 50% 的细胞活力,同时采集样品浓度低至 25 μg/ml 5-FU 的释放百分比降低 40% 表明释放时间更长,这将能够减少需要给药的剂量数量。这反过来导致药物 5-FU 引起的副作用减少。此外,载药纳米复合系统对抑制乳腺癌细胞的有效性,从达到 50% 的细胞活力,同时采集样品浓度低至 25 μg/ml 5-FU 的释放百分比降低 40% 表明释放时间更长,这将能够减少需要给药的剂量数量。这反过来导致药物 5-FU 引起的副作用减少。此外,载药纳米复合系统对抑制乳腺癌细胞的有效性,从达到 50% 的细胞活力,同时采集样品浓度低至 25 μg/ml-1,使这种三元纳米复合材料优越且显着。
更新日期:2021-01-22
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