Genome architecture and chromatin dynamics govern the fate and identify of a cell. Recent advances in mapping chromatin landscapes offer valuable tools for the acquisition of accurate information regarding chromatin dynamics. Here we discuss recent findings linking chromatin dynamics to cell fate control. Specifically, chromatin undergoes a binary off/on switch during iPSC reprogramming, closing and opening loci occupied by somatic and pluripotency transcription factors, respectively. This logic of a binary off/on switch may also be operational in cell fate control during normal development and implies that further approaches could potentially be developed to direct cell fate changes both in vitro and in vivo.

中文翻译：

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细胞命运重编程过程中染色质可及性动态

基因组结构和染色质动力学控制细胞的命运和识别。染色质景观绘图的最新进展为获取有关染色质动态的准确信息提供了宝贵的工具。在这里，我们讨论将染色质动力学与细胞命运控制联系起来的最新发现。具体来说，染色质在 iPSC 重编程过程中经历二元关/开开关，分别关闭和打开体细胞转录因子和多能性转录因子占据的基因座。这种二元关/开开关的逻辑也可能在正常发育过程中的细胞命运控制中发挥作用，这意味着可能会开发出进一步的方法来指导体外和体内细胞命运的变化。