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S-Adenosylhomocysteine Analogue of a Fairy Chemical, Imidazole-4-carboxamide, as its Metabolite in Rice and Yeast and Synthetic Investigations of Related Compounds
Journal of Natural Products ( IF 5.1 ) Pub Date : 2021-01-22 , DOI: 10.1021/acs.jnatprod.0c01269 Hitoshi Ouchi 1 , Takuya Namiki 1 , Kenji Iwamoto 1 , Nobuo Matsuzaki 2 , Makoto Inai 1 , Mihaya Kotajima 2 , Jing Wu 3 , Jae-Hoon Choi 2, 2, 3 , Yoko Kimura 2 , Hirofumi Hirai 2, 2, 3 , Xiaonan Xie 4 , Hirokazu Kawagishi 2, 2, 3 , Toshiyuki Kan 1
Journal of Natural Products ( IF 5.1 ) Pub Date : 2021-01-22 , DOI: 10.1021/acs.jnatprod.0c01269 Hitoshi Ouchi 1 , Takuya Namiki 1 , Kenji Iwamoto 1 , Nobuo Matsuzaki 2 , Makoto Inai 1 , Mihaya Kotajima 2 , Jing Wu 3 , Jae-Hoon Choi 2, 2, 3 , Yoko Kimura 2 , Hirofumi Hirai 2, 2, 3 , Xiaonan Xie 4 , Hirokazu Kawagishi 2, 2, 3 , Toshiyuki Kan 1
Affiliation
During the course of our investigations of fairy chemicals (FCs), we found S-ICAr-H (8a), as a metabolite of imidazole-4-carboxamide (ICA) in rice and yeast (Saccharomyces cerevisiae). In order to determine its absolute configuration, an efficient synthetic method of 8a was developed. This synthetic strategy was applicable to the preparation of analogues of 8a that might be biologically very important, such as S-ICAr-M (9), S-AICAr-H (10), and S-AICAr-M (11).
中文翻译:
S-腺苷高半胱氨酸类似物的一种神奇化学物质,咪唑-4-甲酰胺,作为其在水稻和酵母中的代谢物以及相关化合物的合成研究
在我们对神奇化学品 (FC) 的研究过程中,我们发现了S -ICAr-H ( 8a ),它是水稻和酵母 ( Saccharomyces cerevisiae )中咪唑-4-甲酰胺 (ICA) 的代谢物。为了确定其绝对构型,开发了一种有效的8a合成方法。这种合成策略适用于制备可能在生物学上非常重要的8a类似物,例如S -ICAr-M ( 9 )、S -AICAr-H ( 10 ) 和S -AICAr-M ( 11 )。
更新日期:2021-02-26
中文翻译:
S-腺苷高半胱氨酸类似物的一种神奇化学物质,咪唑-4-甲酰胺,作为其在水稻和酵母中的代谢物以及相关化合物的合成研究
在我们对神奇化学品 (FC) 的研究过程中,我们发现了S -ICAr-H ( 8a ),它是水稻和酵母 ( Saccharomyces cerevisiae )中咪唑-4-甲酰胺 (ICA) 的代谢物。为了确定其绝对构型,开发了一种有效的8a合成方法。这种合成策略适用于制备可能在生物学上非常重要的8a类似物,例如S -ICAr-M ( 9 )、S -AICAr-H ( 10 ) 和S -AICAr-M ( 11 )。