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Estimating Lung Deposition of Fungal Spores Using Actual Airborne Spore Concentrations and Physiological Data
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.est.0c05540 Lynn E Secondo 1, 2 , Jessica A Sagona 2, 3 , Leonardo Calderón 2 , Zuocheng Wang 2, 4 , Deborah Plotnik 5 , Jennifer Senick 5 , MaryAnn Sorensen-Allacci 5 , Richard Wener 6 , Clinton J Andrews 5 , Gediminas Mainelis 2
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.est.0c05540 Lynn E Secondo 1, 2 , Jessica A Sagona 2, 3 , Leonardo Calderón 2 , Zuocheng Wang 2, 4 , Deborah Plotnik 5 , Jennifer Senick 5 , MaryAnn Sorensen-Allacci 5 , Richard Wener 6 , Clinton J Andrews 5 , Gediminas Mainelis 2
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Exposure to bioaerosols has been implicated in adverse respiratory symptoms, infectious diseases, and bioterrorism. Although these particles have been measured within residential and occupational settings in multiple studies, the deposition of bioaerosol particles within the human respiratory system has been only minimally explored. This paper uses real-world environmental measurement data of total fungal spores using Air-o-Cell cassettes in 16 different apartments and residents’ physiological data in those apartments to predict respiratory deposition of the spores. The airborne spore concentrations were measured during the spring, summer, and fall. The respiratory deposition of five most prevalent spore genera—Ascospores, Aspergillus, Basidiospores, Cladosporium, and Myxomycetes—was predicted using three empirical models: the Multiple Path Particle Dosimetry model, using both the Yeh and age-specific versions, and the Bioaerosol Adaptation of the International Committee on Radiological Protection’s Lung deposition model. The predicted total deposited number of spores was highest for Ascospores and Cladosporium. While the majority of spores deposit were in the extrathoracic region, there is a significant deposition for both Aspergillus and Cladosporium in the alveolar region, potentially leading to the development of aspergillosis or allergic asthma. Although the dose–response relationship is unknown, the estimate of the actual spore deposition could be the first step in determining such a relationship.
中文翻译:
使用实际空气中的孢子浓度和生理数据估计真菌孢子的肺沉积
接触生物气溶胶与不良呼吸道症状、传染病和生物恐怖主义有关。尽管在多项研究中已在住宅和职业环境中测量了这些颗粒,但对人体呼吸系统内生物气溶胶颗粒的沉积的研究仅很少。本文使用在 16 个不同公寓中使用 Air-o-Cell 盒的总真菌孢子的真实环境测量数据和这些公寓中的居民生理数据来预测孢子的呼吸沉积。在春季、夏季和秋季测量空气中的孢子浓度。五种最普遍的孢子属——子囊孢子、曲霉、担孢子、枝孢菌属和粘菌属——使用三个经验模型进行预测:多路径粒子剂量学模型,使用 Yeh 和特定年龄版本,以及国际放射防护委员会肺沉积模型的生物气溶胶适应模型。Ascospores和Cladosporium的预测总孢子沉积数量最高。虽然大部分孢子沉积在胸外区域,但曲霉属和枝孢属都有显着沉积在肺泡区域,可能导致曲霉菌病或过敏性哮喘的发展。尽管剂量-反应关系未知,但实际孢子沉积的估计可能是确定这种关系的第一步。
更新日期:2021-02-02
中文翻译:
使用实际空气中的孢子浓度和生理数据估计真菌孢子的肺沉积
接触生物气溶胶与不良呼吸道症状、传染病和生物恐怖主义有关。尽管在多项研究中已在住宅和职业环境中测量了这些颗粒,但对人体呼吸系统内生物气溶胶颗粒的沉积的研究仅很少。本文使用在 16 个不同公寓中使用 Air-o-Cell 盒的总真菌孢子的真实环境测量数据和这些公寓中的居民生理数据来预测孢子的呼吸沉积。在春季、夏季和秋季测量空气中的孢子浓度。五种最普遍的孢子属——子囊孢子、曲霉、担孢子、枝孢菌属和粘菌属——使用三个经验模型进行预测:多路径粒子剂量学模型,使用 Yeh 和特定年龄版本,以及国际放射防护委员会肺沉积模型的生物气溶胶适应模型。Ascospores和Cladosporium的预测总孢子沉积数量最高。虽然大部分孢子沉积在胸外区域,但曲霉属和枝孢属都有显着沉积在肺泡区域,可能导致曲霉菌病或过敏性哮喘的发展。尽管剂量-反应关系未知,但实际孢子沉积的估计可能是确定这种关系的第一步。