Background Glioblastoma multiforme (GBM) is the leading cause of death among adult brain cancer patients. Glutathione peroxidase 2 (GPX2), as a factor in oxidative stress, plays an important role in carcinogenesis. However, its role in GBM has not been well established. The study aimed to investigate the clinical significance of GPX2 with GBM prognosis. Methods Data of GBM and healthy individuals were retrospectively collected from oncomine, cancer cell line encyclopedia (CCLE), gene expression profiling interactive analysis (GEPIA), UALCAN, and Human Protein Atlas. GPX2 mRNA expression was first assessed across various cancer types in oncomine and cancer cell lines from CCLE. The mRNA expression of GPX2 was compared between normal and GBM tissues using GEPIA (normal = 207; GBM = 163) and UALCAN (normal = 5; GBM = 156). The GPX2 methylation was analyzed using data from UALCAN (normal = 2; GBM = 140). The prognostic value of GPX2 in GBM was explored in GEPIA and UALCAN using Kaplan–Meier method. STRING database was used to construct protein–protein interaction (PPI) network and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Statistical significance was set as <0.05. Results The current study revealed no significant differences in GPX2 expression between normal and GBM from GEPIA data ( P > 0.05) and UALCAN ( P = 0.257). Patients with higher GPX2 intended to have a poorer prognosis ( P = 0.0089). The KEGG pathways found that chemokine-signaling pathway were the more preferred. Conclusions The findings demonstrated that GPX2 might be a potential diagnosis and prognostic indicator for GBM. Chemokine-signaling pathway may be involved in GPX2 function.

中文翻译：

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谷胱甘肽过氧化物酶2在多形性胶质母细胞瘤中的临床意义

背景 多形性胶质母细胞瘤 (GBM) 是成年脑癌患者死亡的主要原因。谷胱甘肽过氧化物酶2（GPX2）作为氧化应激的一个因子，在致癌作用中起重要作用。然而，它在 GBM 中的作用尚未得到很好的确立。本研究旨在探讨GPX2对GBM预后的临床意义。方法从oncomine、癌细胞系百科全书（CCLE）、基因表达谱交互分析（GEPIA）、UALCAN和人类蛋白质图谱中回顾性收集GBM和健康个体的数据。GPX2 mRNA 表达首先在来自 CCLE 的癌和癌细胞系的各种癌症类型中进行了评估。使用 GEPIA（正常 = 207；GBM = 163）和 UALCAN（正常 = 5；GBM = 156）比较正常和 GBM 组织之间 GPX2 的 mRNA 表达。使用来自 UALCAN 的数据分析 GPX2 甲基化（正常 = 2；GBM = 140）。在 GEPIA 和 UALCAN 中使用 Kaplan-Meier 方法探讨了 GPX2 在 GBM 中的预后价值。STRING数据库用于构建蛋白质-蛋白质相互作用（PPI）网络和京都基因与基因组百科全书（KEGG）通路。统计学意义设定为<0.05。结果目前的研究显示，GEPIA数据（P>0.05）和UALCAN（P=0.257）的GPX2表达在正常和GBM之间没有显着差异。GPX2 较高的患者预后较差（P = 0.0089）。KEGG 通路发现趋化因子信号通路是更优选的。结论 研究结果表明 GPX2 可能是 GBM 的潜在诊断和预后指标。趋化因子信号通路可能参与 GPX2 功能。