Abstract

Purpose

The aim of this study was to retrospectively compare and analyze pregnancy outcomes of patients with uterine fibroids after high intensity focused ultrasound (HIFU) ablation and laparoscopic myomectomy (LM).

Materials and methods

The study group consisted of 346 patients with uterine fibroids who wished to conceive, in which 152 patients received HIFU ablation treatment (HIFU group) and 194 patients received LM treatment (LM group). The parents’ baseline characters were recorded and the pregnancy outcomes were evaluated in a median follow-up time of 42 months (range: 16 ∼ 81) after the treatment, and the differences of the two groups were compared.

Results

Patients with uterine fibroids in HIFU group had a significant shorter pregnancy interval than that in LM group (10 months VS. 13 months, p < .05). No significant differences were observed in pregnancy rate, miscarriage rate, live birth rate, natural pregnancy rate, cesarean section rate, and perinatal complications rate between the HIFU group and the LM group (p > .05). When stratified by age, infertility history, fibroid types, fibroid numbers, and fibroid sizes, there was no statistically significant difference in pregnancy rate between the HIFU group and the LM group (p > .05).

Conclusions

Based on the results from this study, both HIFU and LM can be safely used to treat patients who wish to conceive. The pregnancy outcomes of post-HIFU are similar to that of post-LM.

中文翻译：

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高强度聚焦超声消融和腹腔镜子宫肌瘤切除术后子宫肌瘤患者妊娠结局的比较分析：一项回顾性研究

摘要

目的

这项研究的目的是回顾性比较和分析高强度聚焦超声（HIFU）消融和腹腔镜子宫肌瘤切除术（LM）后子宫肌瘤患者的妊娠结局。

材料和方法

研究组由346名希望受孕的子宫肌瘤患者组成，其中152例接受HIFU消融治疗（HIFU组）和194例接受LM治疗（LM组）。记录父母的基线特征，并在治疗后中位随访42个月（范围：16〜81）中评估妊娠结局，并比较两组之间的差异。

结果

HIFU组子宫肌瘤患者的妊娠间隔明显短于LM组（10个月vs. 13个月，p  <.05）。HIFU组和LM组在妊娠率，流产率，活产率，自然妊娠率，剖宫产率和围产期并发症发生率方面无显着差异（p  > .05）。当按年龄，不孕史，肌瘤类型，肌瘤数目和肌瘤大小进行分层时，HIFU组和LM组之间的妊娠率没有统计学上的显着差异（p  > .05）。

结论

根据这项研究的结果，HIFU和LM均可安全用于治疗希望受孕的患者。HIFU后的妊娠结局与LM后相似。