Aberrant neuronal network activity likely resulting from disturbed interactions of excitatory and inhibitory systems may be a major cause of cognitive deficits in neuropsychiatric diseases, like within the spectrum of schizophrenic phenotypes. In particular, the synchrony and pattern of oscillatory brain activity appears to be disturbed within limbic networks, e.g. between prefrontal cortex and hippocampus. In a rat model of maternal immune activation (MIA), we compared the acute effects of deep brain stimulation within either medial prefrontal cortex or ventral hippocampus with the effects of repetitive transcranial magnetic stimulation (rTMS), using the intermittent theta‐burst protocol (iTBS), on oscillatory activity within limbic structures. Simultaneous local field potential recordings were made from medial prefrontal cortex, ventral hippocampus, nucleus accumbens and rostral part of ventral tegmental area before and after deep brain stimulation in anaesthetized rats previously (~3 h) treated with sham or verum rTMS. We found a waxing and waning pattern of theta and gamma activity in all structures which was less synchronous in particular between medial prefrontal cortex and ventral hippocampus in MIA offspring. Deep brain stimulation in medial prefrontal cortex and pre‐treatment with iTBS‐rTMS partly improved this pattern. Gamma‐theta cross‐frequency coupling was stronger in MIA offspring and could partly be reduced by deep brain stimulation in medial prefrontal cortex. We can confirm aberrant limbic network activity in a rat MIA model, and at least acute normalizing effects of the neuromodulatory methods. It has to be proven whether these procedures can have chronic effects suitable for therapeutic purposes.

中文翻译：

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反复经颅磁和深部脑刺激对发育性精神分裂症大鼠模型振荡活动的长期同步性的影响

兴奋性和抑制性系统相互作用异常可能导致异常的神经元网络活动，可能是神经精神疾病中认知缺陷的主要原因，例如在精神分裂症表型范围内。特别是，振荡性大脑活动的同步性和模式似乎在边缘网络内受到干扰，例如在前额叶皮层和海马之间。在大鼠母体免疫激活（MIA）模型中，我们使用间歇性theta-burst方案（iTBS），比较了内侧前额叶皮层或腹侧海马内深层脑刺激与重复经颅磁刺激（rTMS）的急性作用。 ），有关边缘结构内的振荡活动。同时从内侧前额叶皮层记录了局部场电势，在深部脑刺激之前和之后（约3 h）用假手术或verum rTMS治疗的麻醉大鼠中，腹侧海马，伏隔核和腹侧被盖区的喙状部分在深部脑刺激之前和之后。我们发现所有结构中θ和γ活性的上蜡和下蜡模式在MIA后代中尤其是内侧前额叶皮层和腹侧海马之间不同步。内侧前额叶皮层的深层脑刺激和iTBS-rTMS的预处理可以部分改善这种模式。在MIA后代中，γ-θ跨频耦合更强，并且在前额内侧皮层的深层脑刺激可能会部分降低它。我们可以在大鼠MIA模型中确认异常的边缘网络活动，以及至少神经调节方法的急性正常化作用。