PURPOSE To describe the patients' characteristics, surgical ratio, and outcomes following epilepsy surgery at the newly established Epilepsy Center Frankfurt Rhine-Main. METHODS We retrospectively studied the first 100 consecutive patients, including adult (n = 77) and pediatric (n = 23) patients, with drug-resistant epilepsy who underwent resective or ablative surgical procedures at a single, newly established epilepsy center. Patient characteristics, seizure and neuropsychological outcomes, histopathology, complications, and surgical ratio were analyzed. RESULTS The mean patient age was 28.8 years (children 10.6 years, adults 34.2 years). The mean epilepsy duration was 11.9 years (children 3.9 years, adults 14.3 years), and the mean follow-up was 1.5 years. At the most recent visit, 64% of patients remained completely seizure free [Engel IA]. The rates of perioperative complications and unexpected new neurological deficits were 5%, each. The proportion of patients showing deficits in one or more cognitive domains increased six months after surgery and decreased to presurgical proportions after two years. Symptoms of depression were significantly decreased and quality of life was significantly increased after surgery. The surgical ratio was 25.3%. CONCLUSION Similar postsurgical outcomes were achieved at a newly established epilepsy center compared with long-standing epilepsy centers. The lower time to surgery may reflect a general decrease in time to surgery over the last decade or the improved accessibility of a new epilepsy center in a previously underserved area. The surgical ratio was not lower than reported for established centers.

中文翻译：

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新成立的癫痫中心的术后效果和手术比例：前100个手术

目的 描述新成立的法兰克福莱茵-美因癫痫中心癫痫手术后患者的特征、手术比例和结果。方法 我们回顾性研究了前 100 名连续患者，包括成人 (n = 77) 和儿童 (n = 23) 耐药性癫痫患者，他们在一个新成立的癫痫中心接受了切除或消融手术。分析了患者特征、癫痫发作和神经心理学结果、组织病理学、并发症和手术比例。结果 患者的平均年龄为 28.8 岁（儿童 10.6 岁，成人 34.2 岁）。平均癫痫持续时间为 11.9 年（儿童 3.9 年，成人 14.3 年），平均随访时间为 1.5 年。在最近一次就诊时，64% 的患者完全没有癫痫发作 [Engel IA]。围手术期并发症和意外新神经功能缺损的发生率各为 5%。在一个或多个认知领域出现缺陷的患者比例在手术后 6 个月增加，并在两年后降至术前比例。手术后抑郁症状明显减轻，生活质量显着提高。手术率为25.3%。结论 与长期成立的癫痫中心相比，新成立的癫痫中心获得了相似的术后结果。手术时间的缩短可能反映了过去十年手术时间的普遍减少，或者在以前服务不足的地区新的癫痫中心的可及性有所改善。手术率不低于已建立的中心报告的比例。