This meta-analysis aimed to evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in identifying lymphazdenopathy. PubMed, Web of Science, Embase and the Cochrane Library were searched for relevant articles through September 2020. A total of 16 articles, which included 1787 participants, were analyzed. The summary sensitivity, specificity, positive likelihood ratio (LR), negative LR and diagnostic odds ratio of CEUS for diagnosing lymphadenopathy were 0.88 (0.86–0.90), 0.90 (0.88–0.92), 6.04 (3.67–9.95), 0.15 (0.10–0.21) and 47.38 (23.45–95.66), respectively. The summary receiver operating characteristic (SROC) area under the curve (AUC) was 0.9405. After omitting outliers identified in a bivariate box plot and forest plot, heterogeneity was decreased, and the pooled sensitivity and specificity were 0.87 (0.84–0.90) and 0.87 (0.84–0.90), respectively. Furthermore, the SROC AUC was 0.9327. In conclusion, CEUS has the potential to be a valuable tool for characterizing lymphadenopathy and could provide clinical decision support.

本荟萃分析旨在评估对比增强超声 (CEUS) 在识别淋巴结病方面的诊断准确性。到 2020 年 9 月，在 PubMed、Web of Science、Embase 和 Cochrane 图书馆中搜索了相关文章。共分析了 16 篇文章，包括 1787 名参与者。CEUS 诊断淋巴结病的敏感性、特异性、阳性似然比 (LR)、阴性 LR 和诊断优势比分别为 0.88 (0.86–0.90)、0.90 (0.88–0.92)、6.04 (3.67–9.95)、0.15 (0.10) 0.21) 和 47.38 (23.45–95.66)，分别。总结接受者操作特征 (SROC) 曲线下面积 (AUC) 为 0.9405。在忽略双变量箱形图和森林图中的异常值后，异质性降低，汇总的敏感性和特异性分别为 0.87 (0.84–0.90) 和 0。87 (0.84–0.90)，分别。此外，SROC AUC 为 0.9327。总之，CEUS 有可能成为表征淋巴结病的有价值的工具，并可以提供临床决策支持。