Efficient mechanisms for genomic maintenance (i.e., DNA repair and DNA replication) are crucial for cell survival. Aging and obesity can lead to the dysregulation of genomic maintenance proteins/pathways and are significant risk factors for the development of cancer, metabolic disorders, and other genetic diseases. Mutations in genes that code for proteins involved in DNA repair and DNA replication can also exacerbate aging- and obesity-related disorders and lead to the development of progeroid diseases. In this review, we will discuss the roles of various DNA repair and replication proteins in aging and obesity as well as investigate the possible mechanisms by which aging and obesity can lead to the dysregulation of these proteins and pathways.

基因组维持（即DNA修复和DNA复制）的有效机制对于细胞存活至关重要。衰老和肥胖会导致基因组维持蛋白/通路的失调，并且是癌症、代谢紊乱和其他遗传疾病发展的重要风险因素。编码参与 DNA 修复和 DNA 复制的蛋白质的基因突变也会加剧与衰老和肥胖相关的疾病，并导致早衰症的发展。在这篇综述中，我们将讨论各种 DNA 修复和复制蛋白在衰老和肥胖中的作用，并研究衰老和肥胖导致这些蛋白质和通路失调的可能机制。