The bioactive glasses (BGs)/Cisplatin and magnetic bioactive glasses (MBGs)/Cisplatin were doped into the chitosan (CS)-grafted- poly (ε-caprolactone) (PCL) nanofibers for controlled release of Cisplatin under various pH values and temperatures. The simultaneous effect of chemotherapy and hyperthermia was investigated against MG-63 osteosarcoma cells by treating of cells with Cs-g-PCL/MBGs/Cisplatin under an alternating magnetic field. The synthesized nanofibers were characterized using XRD, FTIR, ¹H NMR, SEM, and EDX analysis. The bioactivity, and drug loading efficiency of fibers were investigated. There was no initial burst release of Cisplatin from BGs/Cisplatin and MBGs/Cisplatin loaded Cs-g-PCL/MBGs nanofibers and the Cisplatin release rate was accelerated under pH of 5.5 and temperature of 43 °C compared with physiological condition. The apoptotic/necrotic effect indicated that 100 μg mL⁻¹ nanofibers was optimum for killing of MG-63 cells. The future researches could be focused on the application of nanofibers as an implantable device next to a bone tumor for bone cancer therapy in vivo.

将生物活性玻璃（BGs / Cisplatin）和磁性生物活性玻璃（MBGs / Cisplatin）掺杂到壳聚糖（CS）接枝的聚（ε-己内酯）（PCL）纳米纤维中，以在各种pH值和温度下控制顺铂的释放。通过在交变磁场下用Cs-g-PCL / MBGs /顺铂处理细胞，研究了化学疗法和热疗对MG-63骨肉瘤细胞的同时作用。使用XRD，FTIR，¹对合成的纳米纤维进行表征1 H NMR，SEM和EDX分析。研究了纤维的生物活性和载药效率。从BGs / Cisplatin和MBGs / Cisplatin负载的Cs-g-PCL / MBGs纳米纤维中没有最初的顺铂突然释放，并且与生理条件相比，在5.5的pH和43°C的温度下，顺铂的释放速率得以加快。细胞凋亡/坏死效应表明100μgmL ^-1纳米纤维最适合杀死MG-63细胞。未来的研究可能集中在纳米纤维作为可植入装置的应用中，该植入装置是用于体内骨癌治疗的毗邻骨肿瘤的装置。