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Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides
Carbohydrate Polymers ( IF 11.2 ) Pub Date : 2021-01-22 , DOI: 10.1016/j.carbpol.2021.117672
Han Xu , Baoxing Shen , Meng Qiao , Robert J. Linhardt , Xing Zhang

Glycans and glycoconjugates in nature include macromolecules with important biological activities and widely distributed in all living organisms. These oligosaccharides and polysaccharides play important roles in a variety of normal physiological and pathological processes, such as cell metastasis, signal transduction, intercellular adhesion, inflammation, and immune response. However, the heterogeneity of naturally occurring glycans and glycoconjugates complicates detailed structure-activity relationship studies resulting in an incomplete understanding of their mechanisms of action and hindering further applications. Therefore, the synthesis of homogeneous, or nearly homogeneous, structurally defined glycans is of great significance for the development of carbohydrate-based drugs. One-pot synthesis represents the fastest strategy to assemble oligosaccharides and polysaccharides, although unfortunately, typically relies on random assembly. In this review, we examine the progress that has been made in the controlled one-pot synthesis of homogeneous or nearly homogeneous oligosaccharides and polysaccharides providing a broad spectrum of options to access size-controlled glycan products.



中文翻译:

一锅合成可控制大小的聚糖,糖缀合物和多糖的最新进展

自然界中的聚糖和糖结合物包括具有重要生物活性并广泛分布于所有活生物体中的大分子。这些寡糖和多糖在各种正常的生理和病理过程中发挥重要作用,例如细胞转移,信号转导,细胞间粘附,炎症和免疫反应。然而,天然存在的聚糖和糖缀合物的异质性使详细的结构-活性关系研究变得复杂,导致对其作用机理的不完全了解,并阻碍了进一步的应用。因此,合成均一的或几乎均一的,在结构上确定的聚糖对于基于碳水化合物的药物的开发具有重要意义。一锅法合成代表了组装寡糖和多糖的最快策略,尽管不幸的是,通常依赖于随机组装。在这篇综述中,我们检查了在均一或接近均一的低聚糖和多糖的受控一锅合成中所取得的进展,该多糖为获得受尺寸控制的聚糖产品提供了广泛的选择范围。

更新日期:2021-02-01
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