当前位置: X-MOL 学术Biomech. Model. Mechanobiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome
Biomechanics and Modeling in Mechanobiology ( IF 3.5 ) Pub Date : 2021-01-22 , DOI: 10.1007/s10237-020-01413-5
Huseyin Enes Salman 1, 2 , Maha Alser 1 , Akshay Shekhar 3, 4 , Russell A Gould 3 , Fatiha M Benslimane 1 , Jonathan T Butcher 3 , Huseyin C Yalcin 1
Affiliation  

Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulation. HLHS usually initiates as localized tissue malformations with no underlying genetic cause, suggesting that disturbed hemodynamics contribute to the embryonic development of these defects. Left atrial ligation (LAL) is a surgical procedure on embryonic chick resulting in a phenotype resembling clinical HLHS. In this study, we investigated disturbed hemodynamics and deteriorated cardiac growth following LAL to investigate possible mechanobiological mechanisms for the embryonic development of HLHS. We integrated techniques such as echocardiography, micro-CT and computational fluid dynamics (CFD) for these analyses. Specifically, LAL procedure causes an immediate flow disturbance over atrioventricular (AV) cushions. At later stages after the heart septation, it causes hemodynamic disturbances in LV. As a consequence of the LAL procedure, the left-AV canal and LV volume decrease in size, and in the opposite way, the right-AV canal and right ventricle volume increase. According to our CFD analysis, LAL results in an immediate decrease in the left AV canal WSS levels for 3.5-day (HH21) pre-septated hearts. For 7-day post-septated hearts (HH30), LAL leads to further reduction in WSS levels in the left AV canal, and relatively increased WSS levels in the right AV canal. This study demonstrates the critical importance of the disturbed hemodynamics during the heart valve and ventricle development.



中文翻译:

左心房结扎驱动改变的流入血流动力学对胚胎心脏发育的影响:左心发育不良综合征产前进展的线索

先天性心脏缺陷 (CHD) 是出生时心脏结构的异常。一种重要的情况是左心发育不良综合征 (HLHS),其中严重发育不良的左心室 (LV) 无法支持体循环。HLHS 通常起始于没有潜在遗传原因的局部组织畸形,这表明紊乱的血流动力学有助于这些缺陷的胚胎发育。左心房结扎术 (LAL) 是一种对胚胎小鸡进行的外科手术,导致类似于临床 HLHS 的表型。在这项研究中,我们调查了 LAL 后血流动力学紊乱和心脏生长恶化,以研究 HLHS 胚胎发育的可能机械生物学机制。我们整合了超声心动图等技术,用于这些分析的微 CT 和计算流体动力学 (CFD)。具体而言,LAL 程序会导致房室 (AV) 垫上的即时流动干扰。在心脏分隔后的后期阶段,它会导致 LV 的血流动力学紊乱。LAL 手术的结果是,左 AV 管和 LV 容积减小,相反,右 AV 管和右心室容积增加。根据我们的 CFD 分析,LAL 导致 3.5 天 (HH21) 预分离心脏的左 AV 管 WSS 水平立即降低。对于分离后 7 天的心脏 (HH30),LAL 导致左 AV 管中 WSS 水平进一步降低,而右 AV 管中 WSS 水平相对增加。这项研究证明了心脏瓣膜和心室发育过程中血流动力学紊乱的重要性。

更新日期:2021-01-22
down
wechat
bug