SemiSynBio is an emerging topic toward the construction of platforms for next-generation information processing. Recent research has indicated its promising prospect toward information processing including algorithm design and pattern manipulation with the DNA TMSD reaction, which is one of the cores of the SemiSynBio technology route. The DNA TMSD reaction is the process in which an invader strand displaces the incumbent strand from the gate strand through initiation at the exposed toehold domain. Also, the DNA TMSD reaction generally involves three processes: toehold association, branch migration and strand disassociation. Herein, we review the recent progress on information processing with the DNA TMSD reaction. We highlight the diverse developments on information processing with the logic circuit, analog circuit, combinational circuit and information relay with the DNA origami structure. Additionally, we explore the current challenges and various trends toward the design and application of the DNA TMSD reaction in future information processing.

中文翻译：

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基于DNA脚趾介导的链置换（TMSD）反应的信息处理

SemiSynBio是构建下一代信息处理平台的新兴话题。最近的研究表明，其在信息处理方面的前景广阔，包括通过DNA TMSD反应进行算法设计和模式操纵，这是SemiSynBio技术路线的核心之一。DNA TMSD反应是这样一个过程，在该过程中，入侵者链通过在暴露的脚趾结构域处引发而将其从门链中置换出来。同样，DNA TMSD反应通常涉及三个过程：脚趾缔合，分支迁移和链解离。本文中，我们回顾了DNA TMSD反应在信息处理方面的最新进展。我们重点介绍了逻辑电路，模拟电路，DNA折纸结构的组合电路和信息中继。此外，我们探讨了在未来信息处理中DNA TMSD反应设计和应用方面的当前挑战和各种趋势。