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Multiple local therapeutics based on nano-hydrogel composites in breast cancer treatment
Journal of Materials Chemistry B ( IF 7 ) Pub Date : 2020-12-17 , DOI: 10.1039/d0tb02737e
Rui-Zhi Tang 1, 2, 3, 4, 5 , Zhen-Zhen Liu 2, 3, 4, 5, 6 , Sai-Sai Gu 2, 3, 4, 5, 6 , Xi-Qiu Liu 2, 3, 4, 5, 6
Affiliation  

The locoregional recurrence of breast cancer after tumor resection represents several clinical challenges, and conventional post-surgical adjuvant therapeutics always bring about significant systemic side effects. Thus, the local therapy strategy has received considerable interest in breast cancer treatment, and hydrogels can function as ideal platforms due to their remarkable properties such as good biocompatibility, biodegradability, flexibility, and multifunctionality. The nano-hydrogel composites can further incorporate the advantages of nanomaterials into the hydrogel system, to fabricate hierarchical structures for stimulating controlled multi-stage release of different therapeutic agents and improving the synergistic effects of combination therapy. In this review, the problems of clinical treatments of breast cancer and properties of hydrogels in current biomedical applications are briefly overviewed. The focus is on recent advances in local therapy based on nano-hydrogel composites for both monotherapy (chemotherapy, photothermal and photodynamic therapy) and combination therapy (dual chemotherapy, photothermal chemotherapy, photothermal immunotherapy, radio-chemotherapy). Moreover, the challenges and perspectives in the development of advanced nano-hydrogel systems are also discussed.

中文翻译:

基于纳米水凝胶复合材料的多种局部疗法在乳腺癌治疗中的应用

肿瘤切除后乳腺癌的局部复发代表了一些临床挑战,并且常规的手术后辅助疗法总是带来明显的全身性副作用。因此,局部治疗策略已经在乳腺癌治疗中引起了极大的兴趣,并且水凝胶由于其非凡的特性(例如良好的生物相容性,生物降解性,柔韧性和多功能性)而可以用作理想的平台。纳米水凝胶复合材料可进一步将纳米材料的优点结合到水凝胶系统中,以制造用于刺激不同治疗剂的受控多阶段释放并改善联合治疗的协同效应的分层结构。在这篇评论中 简要概述了乳腺癌的临床治疗问题和当前生物医学应用中水凝胶的特性。重点是基于纳米水凝胶复合材料的局部治疗在单药治疗(化学疗法,光热和光动力疗法)和组合疗法(双重化学疗法,光热化学疗法,光热免疫疗法,放射化学疗法)方面的最新进展。此外,还讨论了先进纳米水凝胶系统开发中的挑战和前景。放射化学疗法)。此外,还讨论了先进纳米水凝胶系统开发中的挑战和前景。放射化学疗法)。此外,还讨论了先进纳米水凝胶系统开发中的挑战和前景。
更新日期:2021-01-21
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