The human body has a perfect thermoregulatory system to meet the needs of normal life activities. The central regulation of body temperature is mainly explained by the theory of “setting point (setpoint, SP)”. Fever is a positive but nonspecific response of the body to infections and other pyrogens, which causes immune cells to release cytokines, leading to a brain protein-mediated rise in body temperature. Cytokines can be roughly divided into 2 categories: proinflammatory cytokines and anti-inflammatory cytokines. IL-1, TNF-α, and IL-6 are proinflammatory cytokines, whereas IL-4 and IL-10 are anti-inflammatory cytokines. IL-2 is a cytokine that can both activate and inhibit immunity. IL-8 is a neutrophil chemotactic factor, and IFN is a cytokine that plays a key role in the proper induction and maintenance of innate and acquired immunity. This article reviews the pathophysiological characteristics of fever and the cytokines related to fever (IL-2, 4, 6, 8, 10, IFN, TNF, etc.).

中文翻译：

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发热性疾病中的细胞因子

人体具有完善的体温调节系统，可以满足正常生命活动的需要。体温的中枢调节主要用“定点（setpoint，SP）”理论来解释。发烧是身体对感染和其他热原的一种积极但非特异性的反应，这会导致免疫细胞释放细胞因子，导致大脑蛋白质介导的体温升高。细胞因子大致可分为两类：促炎细胞因子和抗炎细胞因子。IL-1、TNF-α 和 IL-6 是促炎细胞因子，而 IL-4 和 IL-10 是抗炎细胞因子。IL-2 是一种细胞因子，可以激活和抑制免疫。IL-8 是一种嗜中性粒细胞趋化因子，而 IFN 是一种细胞因子，在先天性和获得性免疫的适当诱导和维持中起关键作用。等）。