Aim: The aim of this study is to describe the clinical and pathologic features of corneal primary acquired melanosis (PAM) and melanoma. Methods: We describe 3 cases in total: two cases of corneal melanomas and 1 case of corneal PAM. The eyes were processed routinely for histopathological examination. Clinical histories, treatments, and outcomes were reviewed. Results: Corneal melanomas arose from recurrence of conjunctival melanoma or conjunctival PAM at the limbus. One patient had a recurrence after excision of a limbal melanoma, another had a de novo corneal melanoma, and the last patient had corneal PAM in the setting of conjunctival PAM with atypia. All lesions were excised with adjuvant alcohol debridement and cryotherapy with no recurrence ranging from 1 week to 8 years. Conclusions: Corneal melanomas arise at the limbus from corneal PAM or conjunctival atypia. They can appear after excisional removal of a conjunctival melanoma. Surgical excision with alcohol debridement and adjuvant cryotherapy is successful.
Ocul Oncol Pathol

中文翻译：

---

角膜原发性获得性黑变病和黑素瘤的临床和组织病理学特征

目的：本研究的目的是描述角膜原发性获得性黑变病 (PAM) 和黑素瘤的临床和病理特征。方法：我们共描述了 3 例：2 例角膜黑色素瘤和 1 例角膜 PAM。对眼睛进行常规处理以进行组织病理学检查。回顾了临床病史、治疗和结果。结果：角膜黑色素瘤由结膜黑色素瘤或角膜缘结膜PAM复发引起。一名患者在切除角膜缘黑色素瘤后复发，另一名患者患有新发角膜黑色素瘤，最后一名患者在结膜 PAM 与异型性的情况下患有角膜 PAM。所有病灶均通过辅助酒精清创和冷冻疗法切除，1周至8年无复发。结论：角膜黑色素瘤起源于角膜缘 PAM 或结膜异型性。它们可以在结膜黑色素瘤切除后出现。酒精清创和辅助冷冻治疗的手术切除是成功的。
眼肿瘤病理