Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant. Several studies have investigated NAC’s possible therapeutic role in oxidative metabolism and adaptive response to exercise in the athletic population. However, still conflicting questions regarding NAC supplementation need to be clarified. This narrative review aims to re-evaluate the metabolic effects of NAC on exercise-induced oxidative stress and adaptive response developed by athletes against the exercise, especially mitohormetic and sarcohormetic response.

中文翻译：

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补充N-乙酰半胱氨酸如何影响氧化还原调节，特别是在线粒体和肌膜炎的水平：当前观点

运动经常会改变运动员氧化代谢的代谢过程，包括暴露于极端的活性氧中会损害运动表现。因此，研究人员和运动员都一直在研究可能的策略，以改善代谢适应运动引起的氧化应激。由于N-乙酰半胱氨酸（NAC）在生产天然抗氧化剂肝谷胱甘肽中的前体作用，已被用作治疗人类多种疾病的治疗剂。几项研究调查了NAC在运动人群中氧化代谢和运动适应性反应中可能的治疗作用。但是，仍需要澄清有关NAC补充的矛盾问题。