This work aimed to evaluate the effect of adding two different commercial antioxidants (AOX) products to pre-starter and starter diets using low vitamin E (Vit E as DL-α-tocopheryl acetate) levels on the growth performance and oxidative stress of piglets for the first six weeks post-weaning (PW). They were sorted by initial body weight (BW: 6.175 ± 0.931 kg) and randomly allotted to four dietary treatments (with six replicates per treatment): a positive control (PC) and a negative control (NC) diet, with normal and low dose of vitamin E (80 and 15 mg kg⁻¹, respectively), both without AOX; the other two experimental diets with a low dose of vitamin E (LVE) plus LOXIDAN VD100 (LVE + AOX1) or LOXIDAN E Ros (LVE + AOX2). Growth data were recorded, and blood samples were taken, at the beginning (day 0) and at the end of each feeding period: pre-starter and starter (at days 14 and 42, respectively). No differences among dietary treatments were found with respect to growth performance in the pre-starter period (p ≥ 0.05). However, at the end of the starter period, a lower BW was found in piglets fed the NC diet compared to the other dietary treatments. Differences in daily gain and feed conversion ratio were also found either for the starter period or when the whole period was considered (p < 0.05), whereby piglets fed PC or LVE diets supplemented with AOX showed better growth performance compared to piglets fed the NC diet. Regarding Vit E (α-tocopherol) serum levels, there were no differences among treatments at day 0; but the serum values of this vitamin decreased in LVE diets at 14 and 42 days, but not in the PC. On day 42, the highest levels of α-tocopherol in liver were also found in piglets fed PC (p < 0.05). Nevertheless, in general, from a metabolic point of view and after checking the serum biochemical profile of piglets, there were no differences in other oxidative stress markers (p ≥ 0.05). The results showed that the AOX products used were able to compensate for the lower Vit E supply with respect to growth performance in the starter phase. The use of AOXs or usual levels of Vit E in feed constitutes a key factor in achieving optimal growth performance of piglets in the PW period.

中文翻译：

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饲料中商业抗氧化剂对断奶仔猪生长性能和氧化应激状态的影响

这项工作旨在评估使用低维生素E（维生素E为DL-α-生育酚乙酸酯）水平的两种不同的商业抗氧化剂（AOX）产品添加到发酵前和发酵食品中对仔猪生长性能和氧化应激的影响。断奶后的前六周（PW）。将它们按初始体重（体重：6.175±0.931千克）进行分类，并随机分配给四种饮食治疗（每次治疗重复六次）：阳性和低剂量的阳性对照（PC）和阴性对照（NC）维生素E（80和15 mg kg ^-1分别），都没有AOX；另两种实验饮食则低剂量的维生素E（LVE）加LOXIDAN VD100（LVE + AOX1）或LOXIDAN E Ros（LVE + AOX2）。在每个饲喂期的开始（第0天）和结​​束时记录生长数据，并采集血样：发酵前和发酵前（分别在第14天和第42天）。饮食治疗之间没有差异，发现在预起动期间（对于生长性能p ≥0.05）。然而，在开始阶段结束时，与其他饮食疗法相比，饲喂NC饲料的仔猪的BW较低。在开始阶段或考虑整个时期时，还发现日增重和饲料转化率存在差异（p<0.05），因此与添加NC日粮的仔猪相比，饲喂PC或LVE日粮补充AOX的仔猪表现出更好的生长性能。关于Vit E（α-生育酚）血清水平，第0天的治疗之间无差异。但是在LVE饮食中，这种维生素的血清值在第14天和第42天下降，而在PC中没有下降。在第42天，在饲喂PC的仔猪中也发现了肝脏中α-生育酚的最高水平（p <0.05）。然而，一般而言，从新陈代谢的角度来看，在检查仔猪的血清生化特征后，其他氧化应激指标没有差异（p≥0.05）。结果表明，就起始阶段的生长性能而言，所用的AOX产品能够补偿较低的Vit E供应。饲料中使用AOX或通常水平的Vit E是在PW时期实现仔猪最佳生长性能的关键因素。