A suitable microenvironment provided by artificial granules scaffold plays a critical regulatory role in bone repairing progression. Till now, it is still a challenge to prepare large hydroxyapatite granules (millimetre level) which provide beneficial physical and chemical stimulation for bone reconstruction. Herein, we developed a facile synthetic strategy for synthesizing hydroxyapatite granules by a repaid gelling method. Also, the satisfying drug-releasing behavior of these granules further proves their potential prospect for bone tissue engineering as bone filler.

中文翻译：

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—一种制备空心球形羟基磷灰石颗粒用于药物输送的方法—

人工颗粒支架提供的合适的微环境在骨修复过程中起着至关重要的调节作用。到目前为止，制备大羟基磷灰石颗粒（毫米级）仍然是一个挑战，这些颗粒为骨骼的重建提供有益的物理和化学刺激。在本文中，我们开发了一种简便的合成策略，该方法可通过有偿胶凝法合成羟基磷灰石颗粒。而且，这些颗粒令人满意的药物释放行为进一步证明了它们作为骨填充剂用于骨组织工程的潜在前景。