Human herpesvirus 8 (HHV-8) seroprevalence varies geographically and between subpopulations. High seroprevalence rates have been ascribed to men who have sex with men (MSM), African migrants, and HIV-infected individuals. The objective of this study was to determine the seroprevalence of HHV-8 in an Irish population, including specific risk groups. A cross-sectional study of 200 blood donors and 200 genitourinary medicine (GUM) and infectious diseases (ID) clinic patients was performed, with testing for Immunoglobulin G (IgG) antibodies to HHV-8 lytic antigens using a commercial indirect fluorescence assay (Scimedx Corp.). Verification was performed at the Centers for Disease Control and Prevention (CDC). All 200 blood donor samples were negative for HHV-8 IgG antibodies. 21% of GUM and ID patients were positive for HHV-8 IgG antibodies. One hundred of these patients were MSM, 35% of whom were HHV-8 seropositive (46% of HIV-positive MSM and 24% of HIV-negative MSM). Of 100 heterosexual patients, only 7% were HHV-8 seropositive. The absence of seropositivity in 200 Irish blood donors may suggest that Ireland has a low overall population HHV-8 seroprevalence. The proportion of HHV-8 seropositivity in the MSM population was significantly higher than in the heterosexual population and most marked in HIV-positive MSM.

中文翻译：

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爱尔兰献血者、男男性行为者以及异性恋泌尿生殖医学和传染病诊所参加者中人类疱疹病毒 8 的血清阳性率

人类疱疹病毒 8 (HHV-8) 血清阳性率因地域和亚群而异。高血清阳性率归因于男男性行为者 (MSM)、非洲移民和 HIV 感染者。本研究的目的是确定爱尔兰人群（包括特定风险人群）中 HHV-8 的血清阳性率。对 200 名献血者和 200 名泌尿生殖医学 (GUM) 和传染病 (ID) 诊所患者进行了横断面研究，并使用商业间接荧光测定法 (Scimedx) 测试了针对 HHV-8 裂解抗原的免疫球蛋白 G (IgG) 抗体公司）。验证是在疾病控制和预防中心 (CDC) 进行的。所有 200 份献血者样本的 HHV-8 IgG 抗体均呈阴性。21% 的 GUM 和 ID 患者的 HHV-8 IgG 抗体呈阳性。这些患者中有 100 名是 MSM，其中 35% 的人是 HHV-8 血清阳性（46% 的 HIV 阳性 MSM 和 24% 的 HIV 阴性 MSM）。在 100 名异性恋患者中，只有 7% 的 HHV-8 血清阳性。200 名爱尔兰献血者没有血清阳性可能表明爱尔兰的总体人口 HHV-8 血清阳性率较低。MSM 人群中 HHV-8 血清阳性的比例显着高于异性恋人群，在 HIV 阳性 MSM 中最为明显。