Birch reduction of arene carboxylic acids in the presence of chloroacetonitrile affords nitriles and their subsequent catalytic hydrogenation γ‐spirolactams in only 3 steps with excellent stereoselectivities. It is possible to control the degree of saturation by variation of the catalyst at different pressures. Thus, more than 15 new γ‐spirolactams have been synthesized from inexpensive starting materials.

中文翻译：

---

桦木还原芳烃合成γ-螺内酰胺

在氯乙腈存在下将芳烃羧酸进行桦木还原，仅需3个步骤，即可得到腈及其随后的催化加氢γ-螺内酰胺，具有出色的立体选择性。可以通过在不同压力下改变催化剂来控制饱和度。因此，已经用廉价的起始原料合成了15种以上的新型γ-螺内酰胺。