The aim of this study was to investigate the effects of longan flower (LF) water extract on cardiac apoptotic and survival pathways in rat models of fructose-induced metabolic syndrome. The study findings revealed that the levels of glucose, insulin, triglyceride, and cholesterol and TUNEL-positive apoptotic cells were significantly increased in the HF group compared with the control group; whereas, the levels were decreased in the HFLF group. The expressions of Fas, FADD, and activated caspases 8 and 3, as well as the expressions of Bax, Bak, Bax/Bcl-2, Bak/Bcl-xL, cytosolic cytochrome c, and activated caspases 9 and 3 were increased in the HF group were significantly reversed in HFLF administrated group. Furthermore, LF extract increased IGF-1R, p-PI3K, p-Akt, Bcl-2, and Bcl-xL expression compared to HF group. Taken together, the present findings help identify LF as a potential cardioprotective agent that can be effectively used in treating fructose-induced metabolic syndrome.

中文翻译：

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龙眼花提取物对果糖诱导代谢综合征大鼠心脏的抗凋亡和促存活作用

本研究的目的是研究龙眼花 (LF) 水提取物对果糖诱导的代谢综合征大鼠模型中心脏凋亡和存活途径的影响。研究结果显示，与对照组相比，HF组的葡萄糖、胰岛素、甘油三酯、胆固醇和TUNEL阳性凋亡细胞水平显着升高；而 HFLF 组的水平降低。Fas、FADD 和活化的 caspase 8 和 3 的表达，以及 Bax、Bak、Bax/Bcl-2、Bak/Bcl-xL、细胞溶质细胞色素 c 和活化的 caspase 9 和 3 的表达增加。 HF组在HFLF给药组中明显逆转。此外，与 HF 组相比，LF 提取物增加了 IGF-1R、p-PI3K、p-Akt、Bcl-2 和 Bcl-xL 的表达。综合起来，