Guanine quadruplex (G4)‐DNA structures have sparked the interest of many scientists due to their important biological roles and their potential use in molecular nanoelectronics and nanotechnology. The high guanine content in G4‐DNA endows it with mechanical stability, robustness, and improved charge transport properties—attractive attributes for a molecular nanowire. The self‐driven formation of a novel G4‐DNA‐based nanostructure, coined guanine octuplex (G8)‐DNA, is reported herein. Atomic force microscopy and scanning tunneling microscopy characterization of this molecule reveal its organized coiled‐coil structure, which is found to be stable under different temperatures and surrounding conditions. G8‐DNA exhibits enhanced stiffness, mechanical and thermodynamic stability when compared to its parent G4‐DNA. These, along with its high guanine content, make G8‐DNA a compelling new molecule, and a highly prospective candidate for molecular nanoelectronics.

中文翻译：

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从鸟嘌呤四链体形成新型八链体 DNA 分子

鸟嘌呤四链体 (G4)-DNA 结构因其重要的生物学作用及其在分子纳米电子学和纳米技术中的潜在用途而引起了许多科学家的兴趣。G4-DNA 中的高鸟嘌呤含量使其具有机械稳定性、稳健性和改进的电荷传输特性——这是分子纳米线的有吸引力的属性。本文报道了一种新型基于 G4-DNA 的纳米结构的自驱动形成，即创造的鸟嘌呤八链体 (G8)-DNA。该分子的原子力显微镜和扫描隧道显微镜表征揭示了其有组织的盘绕线圈结构，发现该结构在不同温度和周围条件下是稳定的。与其母体 G4-DNA 相比，G8-DNA 表现出增强的刚度、机械和热力学稳定性。这些，