Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad‐spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized “capture and killing” action of bacteriophages, a virus‐like peroxidase‐mimic (V‐POD‐M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal–organic‐framework‐derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO₃, can serve as a peroxo‐complex‐intermediate to reduce the free energy for catalyzing H₂O₂, which mainly benefits the generation of •OH radicals. The unique virus‐like spikes endow the V‐POD‐M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL^–1). Furthermore, the in vivo experiments show that V‐POD‐M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V‐POD‐M provides a promising broad‐spectrum therapy for nonantibiotic disinfection.

中文翻译：

---

生物启发性的尖峰过氧化物酶模拟物用于局部细菌捕获和协同催化灭菌

除了由冠状病毒爆发引起的大流行外，许多其他病原微生物也对人类健康构成毁灭性威胁，例如，病原细菌。由于缺乏广谱抗生素，因此迫切需要开发非抗生素策略来对抗细菌。在此，受细菌噬菌体的局部“捕获和杀灭”作用的启发，合成了类似病毒的过氧化物酶模拟物（V-POD-M），以有效地捕获细菌（中等尖刺结构）和协同催化杀菌（金属-有机框架）衍生的催化核）。实验和理论计算表明，活性化合物MoO ₃可以作为过氧-络合物-中间体来减少催化H ₂ O ₂的自由能。，这主要有利于•OH自由基的产生。独特的病毒样尖峰赋予V‐POD‐M具有快速的细菌捕获和杀死能力（在16 µg mL ^–1时接近100％）。此外，体内实验表明，V‐POD‐M具有与万古霉素相似的消毒处理和伤口皮肤恢复效率。建议这种廉价，耐用且具有高反应性的氧（ROS）催化活性V-POD-M为非抗生素消毒提供了一种有希望的广谱疗法。