Soft biological tissues compromise diverse cell types and extracellular matrix constituents, each of which can possess individual natural configurations, material properties, and rates of turnover. For this reason, mixture-based models of growth (changes in mass) and remodeling (change in microstructure) are well-suited for studying tissue adaptations, disease progression, and responses to injury or clinical intervention. Such approaches also can be used to design improved tissue engineered constructs to repair, replace, or regenerate tissues. Focusing on blood vessels as archetypes of soft tissues, this paper reviews a constrained mixture theory introduced twenty years ago and explores its usage since by contrasting simulations of diverse vascular conditions. The discussion is framed within the concept of mechanical homeostasis, with consideration of solid-fluid interactions, inflammation, and cell signaling highlighting both past accomplishments and future opportunities as we seek to understand better the evolving composition, geometry, and material behaviors of soft tissues under complex conditions.

软生物组织涉及不同的细胞类型和细胞外基质成分，每一种都可以具有单独的自然配置、材料特性和周转率。因此，基于混合的生长（质量变化）和重塑（微观结构变化）模型非常适合研究组织适应、疾病进展以及对损伤或临床干预的反应。此类方法还可用于设计改进的组织工程构建体以修复、替换或再生组织。本文将血管作为软组织的原型，回顾了 20 年前引入的约束混合理论，并通过对比不同血管状况的模拟来探索其用途。讨论是在机械稳态的概念范围内进行的，