As an important amino acid in the body, L-histidine participates in various physiological processes. Therefore, it is of great necessity to establish a rapid and effective method for L-histidine sensing, especially in blood and urine. In this work, a fluorescence sensor for detection of L-histidine was successfully developed using Cu-MOFs/Fe[Formula: see text] sensor. Cu-MOFs with blue emission served as the identification unit and signal source, and Fe[Formula: see text] played the role of “quencher” in this system. Fe[Formula: see text] induced the fluorescence quenching of Cu-MOFs to form Cu-MOFs/Fe[Formula: see text] sensor due to the effect of photoinduced electron transfer (PET). After the addition of L-histidine, Fe[Formula: see text] was captured by L-histidine to form L-histidine-Fe[Formula: see text] complex, which inhibited the PET effect from Cu-MOFs to Fe[Formula: see text], resulting in the fluorescence recovery of Cu-MOFs. With such a design, L-histidine detection was realized with a wide linear range from 1[Formula: see text][Formula: see text]M to 190[Formula: see text][Formula: see text]M. The limit of detection (LOD) was calculated as low as 0.156[Formula: see text][Formula: see text]M. In addition, successful detection of L-histidine in blood serum with high selectivity and sensitivity indicated the real applications and potential diagnostic value of Cu-MOFs/Fe[Formula: see text] system.

中文翻译：

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一种基于铜基金属有机框架的开启荧光传感器，用于灵敏检测 L-组氨酸

作为体内重要的氨基酸，L-组氨酸参与多种生理过程。因此，非常有必要建立一种快速有效的 L-组氨酸传感方法，特别是在血液和尿液中。在这项工作中，利用Cu-MOFs/Fe[公式：见正文]传感器成功开发了一种用于检测L-组氨酸的荧光传感器。具有蓝色发射的Cu-MOFs作为识别单元和信号源，Fe[分子式：见正文]在该系统中起到“猝灭剂”的作用。由于光致电子转移（PET）的作用，Fe[公式：见正文]诱导Cu-MOFs的荧光猝灭形成Cu-MOFs/Fe[公式：见正文]传感器。加入L-组氨酸后，Fe[分子式：见文]被L-组氨酸捕获形成L-组氨酸-Fe[分子式：见文]络合物，抑制了Cu-MOFs对Fe的PET效应[公式：见正文]，导致Cu-MOFs的荧光恢复。通过这样的设计，实现了从1[公式：见正文][公式：见正文]M到190[公式：见正文][公式：见正文]M的宽线性范围内的L-组氨酸检测。检测限 (LOD) 计算为低至 0.156[公式：见正文][公式：见正文]M。此外，血清中L-组氨酸的高选择性和高灵敏度的成功检测表明了Cu-MOFs/Fe[公式：见正文]系统的实际应用和潜在诊断价值。见正文]M. 检测限 (LOD) 计算为低至 0.156[公式：见正文][公式：见正文]M。此外，血清中L-组氨酸的高选择性和高灵敏度的成功检测表明了Cu-MOFs/Fe[公式：见正文]系统的实际应用和潜在诊断价值。见正文]M. 检测限 (LOD) 计算为低至 0.156[公式：见正文][公式：见正文]M。此外，血清中L-组氨酸的高选择性和高灵敏度的成功检测表明了Cu-MOFs/Fe[公式：见正文]系统的实际应用和潜在诊断价值。