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Swept source intraoperative OCT angiography
Journal of Innovative Optical Health Sciences ( IF 2.5 ) Pub Date : 2020-12-22 , DOI: 10.1142/s1793545821400095
Ziyi Zhang 1 , Tiepei Zhu 2 , Tongtong Cao 1 , Zhaoyu Gong 1 , Lin Yao 1 , Kaiyuan Liu 1 , Juan Ye 2 , Peng Li 1, 3
Affiliation  

To accurately guide surgical instruments during ophthalmic procedures, some necessary intraoperative depth perception is required, which standard surgical microscopes supply limitedly. Intraoperative optical coherence tomography (iOCT), combining optical coherence tomography (OCT) technology and surgical microscope, enables noninvasive, real-time and high-resolution cross-sectional imaging. Currently, though iOCT enables structural imaging, little research has been done on intraoperative angiography. In this work, we presented a swept-source intraoperative OCT angiography (SS-iOCTA) system based on a standard surgical microscope, which provides both structural and angiographic images. The feasibility of the proposed SS-iOCTA was confirmed through deep anterior lamellar keratoplasty (DALK) of ex vivo porcine eyes and blood perfusion imaging of in vivo rat cortex. High-resolution intraoperative feedback, including sub-surface structure and angiogram of biological tissue, can be visualized simultaneously with the SS-iOCTA system, which expand the surgeon’s capabilities and could be widely used in clinical surgery.

中文翻译:

扫描源术中OCT血管造影

为了在眼科手术过程中准确地引导手术器械,需要一些必要的术中深度感知,而标准手术显微镜的供应有限。术中光学相干断层扫描 (iOCT) 结合了光学相干断层扫描 (OCT) 技术和手术显微镜,可实现无创、实时和高分辨率的横截面成像。目前,虽然 iOCT 能够实现结构成像,但对术中血管造影的研究很少。在这项工作中,我们提出了一种基于标准手术显微镜的扫描源术中 OCT 血管造影 (SS-iOCTA) 系统,该系统提供结构和血管造影图像。通过体外猪眼的深前板层角膜移植术(DALK)和体内大鼠皮质的血液灌注成像证实了所提出的 SS-iOCTA 的可行性。高分辨率的术中反馈,包括亚表面结构和生物组织的血管造影,可以与 SS-iOCTA 系统同时可视化,扩展了外科医生的能力,可广泛应用于临床手术。
更新日期:2020-12-22
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