Diffusion-ordered NMR spectroscopy (DOSY) serves as a noninvasive spectroscopic method for studying intact mixtures and identifying individual components present in mixtures according to their diffusion behaviors. However, DOSY techniques generally fail to discriminate complex compositions which exhibit crowded or overlapped NMR signals, particularly under adverse magnetic field conditions. Herein, we exploit the spatially selective pure shift-based DOSY strategy to address this challenge by eliminating inhomogeneous line broadenings and extracting pure shift singlets, thereby expediting diffusion analyses on complex mixtures. More importantly, this strategy is further applied to observing and analyzing electro-oxidation processes of blended alcohols, suggesting its potential to monitoring in situ electrochemical reactions. This study demonstrates a meaningful NMR trial for diffusion analysis on complex mixtures under adverse experimental circumstances, and particularly, it provides a proof-of-concept technique for electrochemical studies and shows promising prospects for applications in chemistry, biology, energy, etc.

中文翻译：

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基于空间选择性的基于纯位移的DOSY在逆磁场条件下复杂混合物的扩散分析

扩散有序NMR光谱（DOSY）是一种无创光谱方法，用于研究完整混合物并根据混合物的扩散行为识别混合物中存在的各个成分。但是，DOSY技术通常无法区分显示出拥挤或重叠的NMR信号的复杂成分，尤其是在不利的磁场条件下。在本文中，我们通过基于空间选择性的基于纯移位的DOSY策略来解决此挑战，方法是消除不均匀的行宽并提取纯移位单峰，从而加快复杂混合物的扩散分析。更重要的是，该策略进一步应用于观察和分析混合醇的电氧化过程，表明其在现场监测中的潜力电化学反应。这项研究证明了在不利的实验条件下对复杂混合物进行扩散分析的有意义的NMR试验，尤其是它为电化学研究提供了概念验证技术，并显示了在化学，生物学，能源等领域的应用前景。