Optical imaging of objects embedded within scattering media such as biological tissues suffers from the loss of resolving power. In our previous work, we proposed an approach called collective accumulation of single scattering (CASS) microscopy that attenuates this detrimental effect of multiple light scattering by combining the time-gated detection and spatial input-output correlation. In the present work, we perform a rigorous theoretical analysis on the effect of multiple light scattering to the optical transfer function of CASS microscopy. In particular, the spatial frequency-dependent signal to noise ratio (SNR) is derived depending on the intensity ratio of the single- and multiple-scattered waves. This allows us to determine the depth-dependent resolving power. We conducted experiments using a Siemens star-like target having various spatial frequency components and supported the theoretical derived SNR spectra. Our study provides a theoretical framework for understanding the effect of multiple light scattering in high-resolution and deep-tissue optical imaging

中文翻译：

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存在散射介质的时间门控相干成像的光学传递函数

嵌入在诸如生物组织之类的散射介质中的物体的光学成像遭受分辨能力的损失。在我们以前的工作中，我们提出了一种称为单散射集体累积（CASS）显微镜的方法，该方法通过结合时间选通检测和空间输入输出相关性来减弱多重光散射的这种不利影响。在目前的工作中，我们对多次光散射对CASS显微镜的光学传递函数的影响进行了严格的理论分析。特别地，取决于单散射波和多散射波的强度比来推导与空间频率有关的信噪比（SNR）。这使我们能够确定深度相关的分辨能力。我们使用具有各种空间频率分量的西门子星形目标进行了实验，并支持了理论推导的SNR谱。我们的研究为理解高分辨率和深部组织光学成像中多重光散射的影响提供了理论框架