The co-occurrence among single nucleotide polymorphisms (SNPs), insertions-deletions (InDels), and oligonucleotide repeats has been reported in prokaryote, eukaryote, and chloroplast genomes. Correlations among SNPs, InDels, and repeats have been investigated in the plant family Araceae previously using pair-wise sequence alignments of the chloroplast genomes of two morphotypes of one species, Colocasia esculenta belonging to subfamily Aroideae (crown group), and four species from the subfamily Lemnoideae, a basal group. The family Araceae is a large family comprising 3,645 species in 144 genera, grouped into eight subfamilies. In the current study, we performed 34 comparisons using 27 species from 7 subfamilies of Araceae to determine correlation coefficients among the mutational events at the family, subfamily, and genus levels. We express strength of the correlations as: negligible or very weak (0.10–0.19), weak (0.20–0.29), moderate (0.30–0.39), strong (0.40–0.69), very strong (0.70–0.99), and perfect (1.00). We observed strong/very strong correlations in most comparisons, whereas a few comparisons showed moderate correlations. The average correlation coefficient was recorded as 0.66 between “SNPs and InDels,” 0.50 between “InDels and repeats,” and 0.42 between “SNPs and repeats.” In qualitative analyses, 95–100% of the repeats at family and sub-family level, while 36–86% of the repeats at genus level comparisons co-occurred with SNPs in the same bins. Our findings show that such correlations among mutational events exist throughout Araceae and support the hypothesis of distribution of oligonucleotide repeats as a proxy for mutational hotspots.

在原核生物，真核生物和叶绿体基因组中已经报道了单核苷酸多态性（SNP），插入缺失（InDels）和寡核苷酸重复序列的共现。先前已经使用一种物种的两种形态型的叶绿体基因组的成对序列比对，在天南星科植物中研究了SNP，InDels和重复序列之间的相关性，香芋属于伞形亚科（冠状群），以及伞形亚科的四个基类。天南科（Araceae）是一个大型科，包括144个属的3,645种，分为八个亚科。在当前的研究中，我们使用了天南星科7个亚科的27个物种进行了34次比较，以确定该家族，亚科和属水平的突变事件之间的相关系数。我们将相关强度表示为：可以忽略不计或非常弱（0.10–0.19），弱（0.20–0.29），中等（0.30–0.39），强（0.40–0.69），非常强（0.70–0.99）和完美（ 1.00）。在大多数比较中，我们观察到强/非常强的相关性，而少数比较显示出中等的相关性。“ SNP和InDels”之间的平均相关系数记录为0.66，“ InDels和重复序列”之间的平均相关系数为0，0。在“ SNP和重复序列”之间为42。在定性分析中，在同一箱中，在家庭和亚科水平重复的95–100％重复发生，而在属水平比较中重复的36–86％与SNP并发。我们的研究结果表明，突变事件之间的这种相关性在整个天南星科中都存在，并支持寡核苷酸重复序列的分布作为突变热点代理的假设。