Amphiphilic thermoresponsive copolymer bottlebrushes based on methoxy oligo(ethylene glycol)7 methacrylate and alkoxy(C12–C14) oligo(ethylene glycol)6 methacrylate have been successfully synthesized via RAFT and conventional free-radical polymerization in toluene. The thermoresponsive behavior of the copolymers in dilute aqueous solutions was studied by turbidimetry and laser light scattering. In water, the copolymer brushes form flower-like micelles with a hydrophobic core consisting of a polymer backbone and alkyl(C12–C14) groups and poly(ethylene glycol) linear chains and loops forming a hydrophilic shell. The size and aggregation number of the micelles and the cloud point of solutions were found to depend on the copolymer composition and chain length, as well as on the synthesis method. The conditions needed for the formation of uni- and multimolecular micelles were determined. Fluorescence techniques were used to determine the CMC of the copolymers and the drug loading capacity of the micelles using pyrene as a model hydrophobic drug. Amphiphilic thermoresponsive copolymer bottlebrushes based on methoxy oligo(ethylene glycol) methacrylate (MOEGM) and alkoxy(C12-C14) oligo(ethylene glycol) methacrylate (DOEGM) have been synthesized via RAFT and conventional free-radical polymerization in toluene. In water, these copolymer brushes form flower-like micelles with a hydrophobic core consisting of a polymer backbone and alkyl(C12–C14) groups and poly(ethylene glycol) linear chains and loops forming a hydrophilic shell. The size and aggregation number of the micelles depend on the copolymer composition and chain length, as well as on the synthesis method.

中文翻译：

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两亲热响应共聚物瓶刷：合成、表征和自组装成花状胶束的研究

基于甲氧基低聚（乙二醇）7 甲基丙烯酸酯和烷氧基（C12-C14）低聚（乙二醇）6 甲基丙烯酸酯的两亲热响应共聚物瓶刷已通过 RAFT 和常规的甲苯自由基聚合成功合成。通过比浊法和激光散射研究了共聚物在稀水溶液中的热响应行为。在水中，共聚物刷形成花状胶束，其疏水核由聚合物主链和烷基（C12-C14）基团和聚（乙二醇）线性链和环组成，形成亲水壳。发现胶束的大小和聚集数以及溶液的浊点取决于共聚物组成和链长，以及合成方法。确定形成单分子和多分子胶束所需的条件。荧光技术用于确定共聚物的 CMC 和胶束的载药量，使用芘作为模型疏水性药物。基于甲氧基低聚（乙二醇）甲基丙烯酸酯（MOEGM）和烷氧基（C12-C14）低聚（乙二醇）甲基丙烯酸酯（DOEGM）的两亲热响应共聚物瓶刷已通过 RAFT 和常规自由基聚合在甲苯中合成。在水中，这些共聚物刷形成花状胶束，其疏水核由聚合物主链和烷基（C12-C14）基团和聚（乙二醇）线性链和环组成，形成亲水壳。胶束的大小和聚集数取决于共聚物的组成和链长，