Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds. There has been considerable scientific interest in the turn of this century in the synthesis of these N‐containing heterocycles as they are prevalent in many alkaloids and also possess striking biological activities including antibacterial, antifungal, antitumor activities. In this regard, a number of synthetic approaches toward the construction of phenanthridine moieties with various substituents, and to increase their yield have been developed by the synthetic organic community. Even though many researchers have developed various innovative methods for the synthesis of phenanthridine derivatives for the past few years, still there is substantial scope for the discovery of novel synthetic methods. In this review, the latest developments in the diverse synthetic strategies of phenanthridine derivatives in the presence and absence of metals were described. The present review also enlightens the use of different reagents, the diversity of the substrates identified, and the plausible mechanisms unravelled towards the construction of these biologically relevant scaffolds.

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菲啶的合成及其机理的最新趋势

菲啶衍生物是最深入研究的生物活性化合物家族之一。在本世纪初，这些N的合成已经引起了相当大的科学兴趣。含杂环，因为它们在许多生物碱中普遍存在，并且还具有惊人的生物学活性，包括抗菌，抗真菌，抗肿瘤活性。在这方面，合成有机社区已开发出许多合成方法来构建具有各种取代基的菲啶部分，并提高其收率。尽管在过去的几年中，许多研究人员已经开发出各种创新的方法来合成菲啶衍生物，但仍然有很大的发现新合成方法的空间。在这篇综述中，描述了在存在和不存在金属的情况下菲啶衍生物的多种合成策略的最新进展。本综述还启发了不同试剂的使用，