Targeting metabolic regulation in cancer cells through metabolic reprogramming is of interest among researchers with regard to preferential cancer cell killing. Evidence indicates that the combination of metabolic modifiers with anticancer therapies attains the expected therapeutic efficiency, suggesting a potential for selective cancer cell death. Here, we have shown that the use of 2‐deoxy‐d‐glucose, a metabolic modifier, enhances the efficiency of air gas plasma treatment at lower doses, resulting in cellular energy loss, which can be attributed to metabolic energy crisis in mitochondria. Interestingly, this novel approach is selective for solid cancer cells over normal cells, thus displaying great potential for increasing nonthermal plasma activity.

中文翻译：

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糖酵解抑制剂可诱导固体癌细胞发生代谢危机，从而增强血浆冷诱导的细胞死亡

通过代谢重编程靶向癌细胞中的代谢调节是研究人员对优先杀死癌细胞的兴趣。有证据表明，将代谢调节剂与抗癌疗法结合使用可达到预期的治疗效果，这提示选择性癌细胞死亡的可能性。这里，我们已经表明，使用2-脱氧的d -葡萄糖，代谢调节剂，提高空气气体等离子体处理的效率在较低剂量下，导致细胞的能量损失，它可以在线粒体归因于代谢能源危机。有趣的是，这种新方法对实体癌细胞具有比正常细胞更高的选择性，因此显示出增加非热血浆活性的巨大潜力。