We developed and tested a 90Sr/90Y generator that using combined columns containing Sr resin and DGA resin. The chromatographic columns were fabricated and then packed with resin contents. Optimization of the columns based on HNO3 and HCl media carried out. The results showed that the value of 90Y with respect to 90Sr for final product was 5 × 106 with a high efficiency of separation (> 99%). The results suggested that the separation of 90Y by the combined Sr/DGA resin columns have a potential to reach high radionuclide purity suitable for radiopharmaceuticals preparation based on peptides, antibodies and particulates labeled with 90Y.

中文翻译：

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使用含有 Sr 树脂和 DGA 树脂的组合柱，通过 90Sr-90Y 色谱发生器制备 90Y 用于放射性核素治疗

我们开发并测试了使用包含 Sr 树脂和 DGA 树脂的组合柱的 90Sr/90Y 发生器。制造色谱柱，然后填充树脂内容物。对基于 HNO3 和 HCl 介质的色谱柱进行了优化。结果表明，最终产品的 90Y 相对于 90Sr 的值为 5 × 106，具有高分离效率（> 99%）。结果表明，结合 Sr/DGA 树脂柱分离 90Y 有可能达到高放射性核素纯度，适用于基于 90Y 标记的肽、抗体和颗粒的放射性药物制备。