Tumor-targeted superfluorinated micellar probe for sensitive in vivo 19F-MRI,Nanoscale

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Tumor-targeted superfluorinated micellar probe for sensitive in vivo 19F-MRI
Nanoscale ( IF 6.7 ) Pub Date : 2020-12-22 , DOI: 10.1039/d0nr08200g
Lucie Jamgotchian _{1,

2,

3,

4,

5} , Solenne Vaillant _{1,

2,

6,

7,

8} , Erwan Selingue _{1,

2,

6,

7,

8} , Anaelle Doerflinger _{1,

2,

3,

4,

5} , Agathe Belime _{1,

2,

3,

4,

5} , Marie Vandamme _{1,

2,

6,

9,

10} , Guillaume Pinna _{1,

2,

6,

9,

10} , Wai Li Ling _{2,

6,

11,

12,

13} , Edmond Gravel _{1,

2,

3,

4,

5} , Sébastien Mériaux _{1,

2,

6,

7,

8} , Eric Doris _{1,

2,

3,

4,

5}

Affiliation

We describe herein the assembly and in vivo evaluation of a tailor-made micellar carrier system designed for the optimized encapsulation of a superfluorinated MRI probe and further targeting of solid tumors. The in vivo validation was carried out on MC38 tumor-bearing mice which allowed the confirmation of the efficient targeting properties of the nano-carrier, as monitored by ¹⁹F-MRI.

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