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Lesions associated with Bartonella taylorii–like bacterium infection in a free-ranging, young-of-the-year raccoon from Prince Edward Island, Canada
The Journal of Veterinary Diagnostic Investigation ( IF 1.5 ) Pub Date : 2021-01-19 , DOI: 10.1177/1040638720988515
Heather Fenton 1, 2 , Scott McBurney 2 , Elizabeth J Elsmo 1, 3 , Christopher A Cleveland 4 , Michael J Yabsley 4
Affiliation  

A young-of-the year, female raccoon was presented with clinical signs of weakness and tremors. The raccoon was euthanized, and autopsy findings included poor body condition, diffuse lymphadenopathy, and pale, firm kidneys with petechial hemorrhages throughout the renal cortex. Histologic lesions included systemic fibrinoid vascular necrosis and severe renal lesions, including lymphoplasmacytic interstitial nephritis and fibrinosuppurative glomerulonephritis. Inflammatory vascular lesions were also present within the uvea, heart, lymph nodes, and the lamina propria of the gastric wall. Ancillary testing was negative for Borrelia burgdorferi, Leptospira sp., Aleutian disease virus, canine distemper virus, feline coronavirus, porcine circovirus 2, and rabies virus. Transmission electron microscopy revealed large numbers of ~1.3 × 0.35 µm bacterial rods surrounded by a trilaminar cell wall located within the glomeruli and associated with aggregates of fibrin and vascular damage. Analysis of partial citrate synthase gene and 16S-23S ribosomal RNA intergenic spacer region sequences from kidney tissue confirmed that the organism was a Bartonella spp. that was related to numerous Bartonella spp. from shrews in Europe. This group formed a sister clade to the genetically diverse Bartonella taylorii group that has been reported from a wide range of Eurasian rodent and flea species.



中文翻译:

来自加拿大爱德华王子岛的一只自由放养的年幼浣熊中与泰洛氏巴尔通体样细菌感染相关的病变

一只年幼的雌性浣熊出现了虚弱和颤抖的临床症状。这只浣熊被安乐死,尸检结果包括身体状况不佳、弥漫性淋巴结肿大、肾脏苍白、坚硬,整个肾皮质有点状出血。组织学病变包括系统性纤维蛋白样血管坏死和严重的肾脏病变,包括淋巴浆细胞性间质性肾炎和纤维蛋白化脓性肾小球肾炎。炎症性血管病变也存在于葡萄膜、心脏、淋巴结和胃壁固有层内。伯氏疏螺旋体钩端螺旋体辅助检测阴性sp.、阿留申病病毒、犬瘟热病毒、猫冠状病毒、猪圆环病毒 2 和狂犬病病毒。透射电子显微镜显示大量约 1.3 × 0.35 µm 的细菌棒被位于肾小球内的三层细胞壁包围,并与纤维蛋白聚集和血管损伤有关。对来自肾组织的部分柠檬酸合酶基因和 16S-23S 核糖体 RNA 基因间隔区序列的分析证实,该生物体是巴尔通体。这与许多巴尔通体有关。来自欧洲的鼩鼱。该组形成了遗传多样的Bartonella taylorii组的姐妹分支,据报道该组来自广泛的欧亚啮齿动物和跳蚤物种。

更新日期:2021-01-19
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