The transition from mild cognitive impairment (MCI) to dementia can only be understood backwards; but it must be lived forwards. Group-wise risk factors are known—but for trials and prognostication, individual risk prediction is needed. Using plasma biomarkers, researchers created models using 573 patients with MCI. The model that combines tau phosphorylated at threonine 181 (P-tau181) and neurofilament light (but not Aβ42/Aβ40), had the best performance. The area under the curve = 0.88 for 4-year conversion to Alzheimer’s was stronger than a basic model of age, sex, education and baseline cognition, and performed similarly to cerebrospinal fluid biomarkers. Nat …

中文翻译：

---

岩相学

从轻度认知障碍（MCI）到痴呆的转变只能倒退理解；但是它必须向前发展。分组风险因素是已知的，但对于试验和预后，需要个体风险预测。研究人员使用血浆生物标记物为573名MCI患者创建了模型。将在苏氨酸181磷酸化的tau（P-tau181）和神经丝光（但不是Aβ42/Aβ40）结合在一起的模型具有最佳性能。曲线下的面积= 0.88（对于4年向阿尔茨海默氏症的转化）比年龄，性别，教育程度和基线认知的基本模型强，并且与脑脊液生物标志物的表现相似。纳特...