The excitatory neurotransmitter glutamate triggers a Ca2+ rise and the extension of processes in astrocytes. Our results suggest that kainic acid receptors (KAR) can independently initiate glutamate signaling in astrocytoma U118-MG cells. The natural product kainic acid triggered glioexcitablity in cells and was inhibited by the KAR antagonist CNQX, but its activity was lower than glutamate on KARs. We created a new heteroaryl kainoid based on rational design: aminooxadiazolyl kainic acid 1 (AODKA). AODKA induced a larger calcium influx and a faster processes extension than kainic acid in U118-MG cells. AODKA is a new tool to study KAR activity in the nervous system.

中文翻译：

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氨基恶二唑基海藻酸显示海藻酸受体有助于星形细胞瘤谷氨酸信号传导

兴奋性神经递质谷氨酸触发星形胶质细胞中Ca2 +的升高和过程的扩展。我们的结果表明，海藻酸受体（KAR）可以独立启动星形细胞瘤U118-MG细胞中的谷氨酸信号。天然产物海藻酸触发细胞胶质兴奋性，并被KAR拮抗剂CNQX抑制，但其活性低于KARs的谷氨酸。我们根据合理的设计创建了一种新的杂芳基类胡萝卜素：氨基恶二唑基海藻酸1（AODKA）。在U118-MG细胞中，AODKA比海藻酸诱导更大的钙内流和更快的过程扩展。AODKA是研究神经系统中KAR活性的新工具。