Second generation (2G) ethanol is produced through the use of lignocellulosic biomass. However, the pretreatment processes generates a variety of molecules (furan derivatives, phenolic compounds and organic acids) that act as inhibitors of microbial metabolism, and thus reduce the efficiency of the fermentation step in this process. In this context, the present study aimed to investigate the effect of furan derivatives on the physiology of lactic acid bacteria (LAB) strains that are potential contaminants of ethanol production. Homofermentative and heterofermentative strains of laboratory LAB and isolated from first generation ethanol fermentation were used. LAB strains were challenge to grow in the presence of furfural and hydroxymethyylfurfural (HMF). We found that the effect of HMF and furfural on the growth rate of LAB is dependent of the metabolic type, and growth kinetics in the presence of these compounds is enhanced for heterofermentative LAB, whereas is inhibitory to homofermentative LAB. Sugar consumption and product formation were also enhanced in the presence of furaldehydes in heterofermentative LAB, that displayed an effective detoxification kinetics when compared to the homofermentative LAB. This knowledge is important because LAB can be explored both within the scope of bio-detoxification, being applied before the fermentation.

中文翻译：

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木质纤维素抑制化合物对同型和异型发酵乳杆菌的影响不同

通过使用木质纤维素生物质生产第二代（2G）乙醇。但是，预处理过程会产生多种分子（呋喃衍生物，酚类化合物和有机酸），这些分子充当微生物代谢的抑制剂，因此会降低该过程中发酵步骤的效率。在这种情况下，本研究旨在研究呋喃衍生物对乳酸菌（LAB）菌株的生理影响，而乳酸菌是乙醇生产的潜在污染物。使用实验室LAB的同型发酵和异型发酵菌株，并从第一代乙醇发酵中分离出来。在糠醛和羟甲基糠醛（HMF）存在下，LAB菌株难以生长。我们发现，HMF和糠醛对LAB的生长速率的影响取决于代谢类型，并且对于异发酵LAB而言，存在这些化合物时的生长动力学得到增强，而对同发酵LAB则具有抑制作用。在异发酵的LAB中存在甲醛时，糖的消耗和产物的形成也得到了增强，与同发酵的LAB相比，糖展示了有效的排毒动力学。该知识很重要，因为可以在发酵之前应用的生物解毒范围内探索LAB。在异发酵的LAB中存在甲醛时，糖的消耗和产物的形成也得到了增强，与同发酵的LAB相比，糖展示了有效的排毒动力学。该知识很重要，因为可以在发酵之前应用的生物解毒范围内探索LAB。在异发酵的LAB中存在甲醛时，糖的消耗和产物的形成也得到了增强，与同发酵的LAB相比，糖展示了有效的排毒动力学。该知识很重要，因为可以在发酵之前应用的生物解毒范围内探索LAB。