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Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
Pharmaceutics ( IF 5.4 ) Pub Date : 2021-01-19 , DOI: 10.3390/pharmaceutics13010124
Maria D Auxtero 1 , Susana Chalante 1 , Mário R Abade 1 , Rui Jorge 1, 2, 3 , Ana I Fernandes 1
Affiliation  

Late-life mild cognitive impairment and dementia represent a significant burden on healthcare systems and a unique challenge to medicine due to the currently limited treatment options. Plant phytochemicals have been considered in alternative, or complementary, prevention and treatment strategies. Herbals are consumed as such, or as food supplements, whose consumption has recently increased. However, these products are not exempt from adverse effects and pharmacological interactions, presenting a special risk in aged, polymedicated individuals. Understanding pharmacokinetic and pharmacodynamic interactions is warranted to avoid undesirable adverse drug reactions, which may result in unwanted side-effects or therapeutic failure. The present study reviews the potential interactions between selected bioactive compounds (170) used by seniors for cognitive enhancement and representative drugs of 10 pharmacotherapeutic classes commonly prescribed to the middle-aged adults, often multimorbid and polymedicated, to anticipate and prevent risks arising from their co-administration. A literature review was conducted to identify mutual targets affected (inhibition/induction/substrate), the frequency of which was taken as a measure of potential interaction. Although a limited number of drugs were studied, from this work, interaction with other drugs affecting the same targets may be anticipated and prevented, constituting a valuable tool for healthcare professionals in clinical practice.

中文翻译:

治疗年龄相关认知功能障碍的潜在草药-药物相互作用

由于目前治疗选择有限,晚年轻度认知障碍和痴呆症给医疗保健系统带来了沉重负担,也给医学带来了独特的挑战。植物化学物质已被考虑用于替代或补充的预防和治疗策略。草药本身或作为食品补充剂被消费,其消费量最近有所增加。然而,这些产品并不能免除不良反应和药理相互作用,对老年、服用多种药物的个体存在特殊风险。了解药代动力学和药效学相互作用有助于避免不良药物反应,这些不良反应可能导致不良副作用或治疗失败。本研究回顾了老年人用于增强认知的选定生物活性化合物 (170) 与中年成年人常用的 10 种药物治疗类别的代表性药物(通常患有多种疾病和多种药物)之间的潜在相互作用,以预测和预防因中年人的认知障碍而产生的风险。 -行政。进行文献综述以确定受影响的共同目标(抑制/诱导/底物),其频率被视为潜在相互作用的衡量标准。尽管研究的药物数量有限,但从这项工作中,可以预测并预防与影响相同目标的其他药物的相互作用,这为医疗保健专业人员在临床实践中构成了宝贵的工具。
更新日期:2021-01-19
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