Fungal endophytes are well-established sources of biologically active natural compounds with many producing pharmacologically valuable specific plant-derived products. This review details typical plant-derived medicinal compounds of several classes, including alkaloids, coumarins, flavonoids, glycosides, lignans, phenylpropanoids, quinones, saponins, terpenoids, and xanthones that are produced by endophytic fungi. This review covers the studies carried out since the first report of taxol biosynthesis by endophytic Taxomyces andreanae in 1993 up to mid-2020. The article also highlights the prospects of endophyte-dependent biosynthesis of such plant-derived pharmacologically active compounds and the bottlenecks in the commercialization of this novel approach in the area of drug discovery. After recent updates in the field of ‘omics’ and ‘one strain many compounds’ (OSMAC) approach, fungal endophytes have emerged as strong unconventional source of such prized products.

中文翻译：

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真菌内生菌作为植物源生物活性化合物的有效来源及其在天然产物药物发现中的前景应用：见解、途径和挑战

真菌内生菌是生物活性天然化合物的公认来源，其中许多可产生具有药理学价值的特定植物衍生产品。这篇综述详细介绍了几类典型的植物源药用化合物，包括内生真菌产生的生物碱、香豆素、类黄酮、糖苷、木酚素、苯丙素、醌、皂苷、萜类化合物和氧杂蒽酮。本综述涵盖了自 1993 年首次报道内生紫杉醇生物合成以来至 2020 年中期所进行的研究。该文章还强调了此类植物源药理活性化合物的内生菌依赖性生物合成的前景以及这种新方法在药物发现领域商业化的瓶颈。经过最近“组学”和“一株多种化合物”（OSMAC）方法领域的更新，内生真菌已成为此类珍贵产品的强大非传统来源。