mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target “undruggable” diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.

中文翻译：

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mRNA 增强细胞疗法和心血管再生

在 COVID-19 大流行期间，全球呼吁开发疗法，mRNA 已成为重要的生物分子。合成的体外转录 (IVT) mRNA 可以被设计为模拟天然存在的 mRNA，并且可以用作针对“不可药性”疾病的工具。RNA 疗法领域的最新进展解决了这种药物分子固有的挑战，这种方法现在正应用于从癌症免疫疗法到疫苗开发的多种治疗方式。在这篇综述中，我们讨论了 mRNA 用于干细胞生成或增强以达到心血管再生的目的。