Prostate cancer is one of the most frequent cancers in men and is a common cause of cancer-related death. Despite significant progress in the diagnosis and treatment of this tumor, patients who relapse after radical treatments inevitably develop metastatic disease. Patient stratification is therefore key in this type of cancer, and there is an urgent need for prognostic biomarkers that can define patients’ risk of cancer-related death. In the last 10 years, multiple prognostic factors have been identified and studied. Here, we review the literature available and discuss the most common aberrant genomic pathways in metastatic castration-resistant prostate cancer shown to have a prognostic relevance in this setting.

中文翻译：

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转移性去势抵抗性前列腺癌的新预后生物标志物

前列腺癌是男性中最常见的癌症之一，并且是与癌症相关的死亡的常见原因。尽管在该肿瘤的诊断和治疗方面取得了重大进展，但在根治性治疗后复发的患者仍不可避免地发展成转移性疾病。因此，患者分层是这类癌症的关键，并且迫切需要能够确定患者癌症相关死亡风险的预后生物标志物。在过去的十年中，已经确定并研究了多种预后因素。在这里，我们回顾了现有文献，并讨论了在这种情况下具有预后意义的转移去势抵抗性前列腺癌中最常见的异常基因组途径。