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α-Glucosidic Hydroquinone Derivatives from Viburnum Erosum
ChemRxiv Pub Date : 2021-01-19
Jinyoung Park, Jiho Lee, Hyeon S. Jang, Birang Jeong, Seong Y. Choi, Juyeol Kim, Yong S. Kwon, Heejung Yang

Six new compounds (1−6) were isolated from the leaves of Viburnum erosum along with four known compounds 7−10. The structures were determined by NMR and MS spectroscopic analyses, and their absolute configurations were established by chemical and spectroscopic methods. Compounds 1–6 were α-glucosidic hydroquinone derivatives with different linear monoterpenoid structures. Compounds 1−10 were also evaluated for their tyrosinase inhibitory activities, and 10 showed potent inhibition of tyrosinase enzyme with IC50 of 37.9 μM compared to 47.6 μM of the positive control (β-arbutin).

中文翻译:

荚burn的α-葡萄糖苷对苯二酚衍生物

从荚Vi荚sum的叶子中分离出六个新化合物(1-6),以及四个已知化合物7-10。通过NMR和MS光谱分析确定结构,并通过化学和光谱方法确定它们的绝对构型。化合物1-6是具有不同线性单萜结构的α-葡萄糖苷氢醌衍生物。还评估了化合物1-10的酪氨酸酶抑制活性,化合物10显示出对酪氨酸酶的有效抑制作用,IC50为37.9μM,而阳性对照(β-熊果苷)为47.6μM。
更新日期:2021-01-19
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