Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect transistor (EG-FET) for the recognition of cortisol in biological buffers within the Debye screening length. The device shows promising experimental features for real-time monitoring of the circadian rhythm of cortisol in human sweat. We report a hysteresis-free EG-FET with a voltage sensitivity of the order of 14 mV/decade and current sensitivity up to 80% over the four decades of cortisol concentration. The detection limit is 0.2 nM over a wide range, between 1 nM and 10 µM, of cortisol concentrations in physiological fluid, with negligible drift over time and high selectivity. The dynamic range fully covers those in human sweat. We propose a comprehensive analysis and a unified, predictive analytical mapping of current sensitivity in all regimes of operation.

皮质醇是响应压力而释放的激素，是肾上腺产生的主要糖皮质激素。在这里，我们报告了一种基于铂/石墨烯适体扩展栅场效应晶体管（EG-FET）的无标签检测的可穿戴传感电子芯片，用于识别Debye筛选长度内生物缓冲液中的皮质醇。该设备具有用于实时监测人类汗液中皮质醇昼夜节律的有希望的实验功能。我们报告了在皮质醇浓度的四个十年中，电压灵敏度为14 mV /十阶左右且电流灵敏度高达80％的无磁滞EG-FET。生理液中皮质醇浓度的宽范围（1 nM至10 µM）的检测极限为0.2 nM，随时间的变化可忽略不计，且选择性高。动态范围完全覆盖了人体汗液。我们建议对所有操作方案中的当前灵敏度进行全面分析和统一的预测性分析映射。