Herein, we report a novel palladium (Pd)-catalyzed asymmetric domino Heck/carbocyclization/Suzuki reaction of N-(2-bromoaryl)-2-naphthylacrylamides. The reaction involves a novel and enantioselective dearomative 1,2-insertion of the naphthalene group, thus providing a unique dearomatization strategy of nonactivated naphthalenes. A new phosphoramidite ligand L12, which displayed excellent reactivity and enantioselectivity in the reaction, has been developed. The reaction employs readily available starting materials, and provides straightforward access to a diverse array of spirooxindoles bearing three stereogenic centers in high yields under mild conditions.

在这里，我们报告了新型钯（Pd）催化的N-（2-溴芳基）-2-萘丙烯酰胺的不对称多米诺Heck /碳环化/ Suzuki反应。该反应涉及萘基团的新颖和对映选择性脱芳香基的1，2-插入，因此提供了非活化萘的独特的脱芳香化策略。一种新的亚磷酰胺配体 L12已经开发出在反应中显示出优异的反应性和对映选择性的化合物。该反应采用容易获得的起始原料，并在温和条件下以高收率直接获得具有3个立体异构中心的多种螺硫辛醇。