To develop highly efficient synthetic reactions is quite important in organic chemistry. Cross dehydrogenative couplings (CDC) utilize C−H bonds of substrates to construct new C−X (X=C, S, O, N, P) bonds. For CDC, the pre‐functionalization of reaction substrates can be avoided and the C−X (X=C, S, O, N, P) bonds can be newly formed by simple and efficient synthesis routes. Meanwhile, water is increasingly used as a substitute for organic solvents in cross‐dehydrogenative coupling because of its rich content, non‐toxicity, and non‐ flammability. In recent years, organic chemists are devoted their efforts to explore the cross dehydrogenative couplings (CDC) in aqueous phase which feature high atom utilization rate and environmental friendliness. Herein, we summarized the recent advances in the construction of C−C, C−S, C−O, C−N, and C−P bonds through CDC reactions of C−H bonds in water.

中文翻译：

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水性介质中CH键的交叉脱氢偶联（CDC）的最新进展

开发高效的合成反应在有机化学中非常重要。交叉脱氢偶联（CDC）利用底物的CH键构建新的C X（X = C，S，O，N，P）键。对于CDC，可以避免反应底物的预官能化，并且可以通过简单有效的合成途径重新形成C-X（X = C，S，O，N，P）键。同时，由于水的含量丰富，无毒且不易燃，因此在交叉脱氢偶联中越来越多地使用水作为有机溶剂的替代品。近年来，有机化学家们致力于研究具有高原子利用率和环境友好性的水相交叉脱氢偶联（CDC）。在这里，我们总结了C，C，S，C，O，CN，